Role of Xanthine-Xanthine Oxidase Systems and Polymorphonuclear Leukocytes in Lipid Peroxidation in Compound 48/80-Induced Gastric Mucosal Injury in Rats
Recent studies have demonstrated that active oxygen species and lipid peroxidation might be involved in the formation of gastric mucosal lesions1–3. Compound 48/80 is a mast cell degranulator to release histamine and serotonin. Repeated administration of a small dose of this agent can induce gastric mucosal injury in rats with a low mortality rate4. This study was designed to evaluate a role of active oxygen species and lipid peroxidation in the pathogenesis of gastric mucosal injury induced by compound 48/80 in rats. Fur- thermore, the role of xanthine-xanthine oxidase systems and polymorphonuclear leukocytes (PMN) for the source of active oxygen species was examined.
KeywordsGastric Mucosa Phorbol Myristate Acetate Active Oxygen Species Superoxide Generation Phorbol Myristate Acetate
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