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Role of Xanthine-Xanthine Oxidase Systems and Polymorphonuclear Leukocytes in Lipid Peroxidation in Compound 48/80-Induced Gastric Mucosal Injury in Rats

  • Toshiki Takemura
  • Toshikazu Yoshikawa
  • Yuji Naito
  • Shigenobu Ueda
  • Toru Tanigawa
  • Shigeru Sugino
  • Motoharu Kondo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

Recent studies have demonstrated that active oxygen species and lipid peroxidation might be involved in the formation of gastric mucosal lesions1–3. Compound 48/80 is a mast cell degranulator to release histamine and serotonin. Repeated administration of a small dose of this agent can induce gastric mucosal injury in rats with a low mortality rate4. This study was designed to evaluate a role of active oxygen species and lipid peroxidation in the pathogenesis of gastric mucosal injury induced by compound 48/80 in rats. Fur- thermore, the role of xanthine-xanthine oxidase systems and polymorphonuclear leukocytes (PMN) for the source of active oxygen species was examined.

Keywords

Gastric Mucosa Phorbol Myristate Acetate Active Oxygen Species Superoxide Generation Phorbol Myristate Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    T. Yoshikawa, H. Miyagawa, N. Yoshida, T. Takemura, T. Tanigawa, S. Sugino, and M. Kondo, Increase in lipid peroxidation in rat gastric mucosal lesions induced by water-immersion restraint stress, J. Clin. Biochem. Nutr. 1:271 (1985)CrossRefGoogle Scholar
  2. 2.
    T. Takemura, T. Yoshikawa, K. Tainaka, Y. Morita, K. Itani, O. Seto, S. Sugino, and M. Kondo, Role of lipid peroxidation in acute gastric mucosal lesions experimentally induced by radio-frequency hyperthermia in rats, J. Clin. Exp. Med. 143: 545 (1987)Google Scholar
  3. 3.
    T. Yoshikawa, N. Yoshida, H. Miyagawa, T. Takemura, T. Tanigawa, S. Sugino, and M. Kondo, Role of lipid peroxidation in gastric mucosal lesions induced by burn shock in rats, J. Clin. Biochem. Nutr. 2: 163 (1987)CrossRefGoogle Scholar
  4. 4.
    K. Takeuchi, H. Ohtsuki, and S. Okabe, Pathogenesis of compound 4–8/80 -induced gastric lesions in rats, Digestive Disease and Science 31: 392 (1986)CrossRefGoogle Scholar
  5. 5.
    H. Ohkawa, N. Ohnishi, and K. Yagi, Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction, Anal. Biochem. 95: 351 (1976)CrossRefGoogle Scholar
  6. 6.
    K. Maejima, K. Miyata, and K. Tomoda, A manganese Superoxide dismutase from serratia marcescens, Agric. Biol. Chem. 47:1537 (1983)CrossRefGoogle Scholar
  7. 7.
    P. A. Ward and C. G. Cochrane, Bound compliment and immunologic injury of blood vessels, J. Exp. Med. 121:215 (1964)CrossRefGoogle Scholar
  8. 8.
    T. Takemura, T. Yoshikawa, O. Seto, T. Tanigawa, K. Tainaka, Y. Morita, N. Yoshida, S. Sugino, and M. Kondo, Role of lipid peroxidation and polymor phonuclear leukocyte-derived oxygen radicals in acute gastric lesions induced by hyperthermic treatment, Jpn. J. Gastroenterol. 2:(1989, submitted)Google Scholar
  9. 9.
    A. Nishida, K. Sugioka, M. Nakano, and K. Yagi, Use of 2-methyl-6-phenyl -3,7-dihydroimidazo(1,2-a)pyrazin-3-one for assay of Superoxide anions in phagocytizing granulocytes, J. Clin. Biochem. Nutr. 1: 5 (1986)CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Toshiki Takemura
    • 1
  • Toshikazu Yoshikawa
    • 1
  • Yuji Naito
    • 1
  • Shigenobu Ueda
    • 1
  • Toru Tanigawa
    • 1
  • Shigeru Sugino
    • 1
  • Motoharu Kondo
    • 1
  1. 1.First Department of MedicineKyoto Prefectural University of MedicineHirokoji, Kamigyo-ku, Kyoto 602Japan

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