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Zinc-Carnosine Chelate Compound (Z-103) Attenuates Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats

  • Y. Naito
  • T. Yoshikawa
  • T. Tanigawa
  • T. Yoneta
  • S. Ueda
  • H. Oyamada
  • T. Takemura
  • S. Sugino
  • M. Kondo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

A novel synthesized agent, zinc N-(3-aminopropionyl)-L-histidine (Z-103, Fig. 1), is a chelate compound that consists of zinc iron and L-carnosine. Carnosine was discovered in 1900 by Gulewitsch and Amiradzibi1 from meat extract, and is reportedly present in the range of 1–20 mM in the skeletal muscle and brain of many animals and humans2. Recently, several reports have described the antioxidative activity of carnosine, such as efficient singlet oxygen scavengers3, peroxy radical scavengers4, efficient chelating agent for copper and other transitional metals4, and Superoxide scavenging activity in the presence of copper or zinc5.

Keywords

Gastric Mucosa Gastric Wall Gastric Mucosal Injury Gastric Mucosal Lesion Gastric Mucosal Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Y. Naito
    • 1
  • T. Yoshikawa
    • 1
  • T. Tanigawa
    • 1
  • T. Yoneta
    • 1
  • S. Ueda
    • 1
  • H. Oyamada
    • 1
  • T. Takemura
    • 1
  • S. Sugino
    • 1
  • M. Kondo
    • 1
  1. 1.First Department of MedicineKyoto Prefectural University of MedicineKamigyo-ku, Kyoto 602Japan

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