Zinc-Carnosine Chelate Compound (Z-103) Attenuates Acute Gastric Mucosal Injury Induced by Ischemia-Reperfusion in Rats
A novel synthesized agent, zinc N-(3-aminopropionyl)-L-histidine (Z-103, Fig. 1), is a chelate compound that consists of zinc iron and L-carnosine. Carnosine was discovered in 1900 by Gulewitsch and Amiradzibi1 from meat extract, and is reportedly present in the range of 1–20 mM in the skeletal muscle and brain of many animals and humans2. Recently, several reports have described the antioxidative activity of carnosine, such as efficient singlet oxygen scavengers3, peroxy radical scavengers4, efficient chelating agent for copper and other transitional metals4, and Superoxide scavenging activity in the presence of copper or zinc5.
KeywordsGastric Mucosa Gastric Wall Gastric Mucosal Injury Gastric Mucosal Lesion Gastric Mucosal Blood Flow
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- 2.C.R.Scriver, T.L.Perry, and W.Nutzenadel : Disorder of beta-alanine, carnosine, and homocarnosine metabolism. in The metabolic basis of inherited disease, J.B.Stanbury et al eds. mcGraw-Hill, New York (1983).Google Scholar
- 3.P.E.Hartman : Interception of toxic agents/mutagens/carcinogens: some of nature’s novel strategies, in Antimutagenesis and anticarcinogenesis mechanism, D.M.Shankel et al eds., Plenum press, New York and London (1988).Google Scholar
- 5.T.Yoshikawa, Y.Naito, T.Tanigawa, T.Yoneta, H.Oyamada, S.Ueda, T.Takemura, S.Sugino, and M.Kondo : Effect of zinc-carnosine chelate Z-103 on the generation of Superoxide anion radicals from hypoxanthine-xanthine oxidase system. J.Clin.Exp.Med., 14–7:927(1988).Google Scholar
- 9.R.L.Willson : Vitamin, selenium, zinc and copper interaction in free radical protection against ill-placed iron. Proceed.Nut.Soc., 4–6:27 (1987).Google Scholar
- 11.T.Yoshikawa : Pathophysiology of ischemia-reperfusion injury. in Medical, biochemical and chemical aspects of free radicals, O.Hayaishi et al eds., Elsevier Sci., Amsterdam.New York.Oxford (1988).Google Scholar
- 12.D.N.Granger, M.E.Hollwarth, and D.A.Parks: Ischemia-reperfusion injury: role of oxygen-derived free radicals. Acta.Physiol.Scand., Suppl.54–8:47 (1986).Google Scholar