Evidence that Calcium Mediates Free Radical Damage Through Activation of Phospholipase A2 During Cold Storage of the Rabbit Kidney
Renal transplantation involves periods of warm and cold ischaemia which often result in poor renal function and death of tubular cells soon after engraftment. There is growing evidence that oxygen derived free radicals are responsible, at least, in part, for reperfusion injury and may be involved in ischaemic damage1. We have shown in previous studies that markers of lipid peroxidation, resulting from oxidative damage, increase in rabbit kidneys following storage2. In addition, we have recently reported evidence for a relationship between altered calcium homeostasis and oxidative damage to the rabbit kidney following cold storage3.
KeywordsFree Fatty Acid Cold Ischaemia Rabbit Kidney Calcium Ionophore A23187 Pentadecanoic Acid
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