Effect of Superoxide Dismutase on the Autoxidation of Hydroquinones Formed During DT-Diaphorase Catalysis and Glutathione Nucleophilic Addition

  • Enrique Cadenas
  • Lars Ernster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Electron-transfer reactions as well as the generation and reactivity of free radicals in biological systems are controlled by thermodynamic-, kinetic-, and environmental factors1. The redox chemistry of hydro- and semi-quinones is in large extent determined by the physico-chemical properties of the molecule, such as the reduction potential and the influ- ence on it of the substitution pattern, by environmental factors, such as pH, solvent cage, solvation energy, and medium polarity, and by kinetic factors, which can allow a reaction -otherwise thermodynamically unlikely- to proceed by exerting a modification on its equilibrium.


Superoxide Dismutase Quinoid Ring Solvent Cage Semiquinone Anion Radical Quinoid Compound 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Enrique Cadenas
    • 1
    • 2
  • Lars Ernster
    • 1
    • 2
  1. 1.Department of Pathology IIUniversity of LinköpingLinköpingSweden
  2. 2.Department of BiochemistryUniversity of StockholmStockholmSweden

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