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Effect of Superoxide Dismutase on the Autoxidation of Hydroquinones Formed During DT-Diaphorase Catalysis and Glutathione Nucleophilic Addition

  • Enrique Cadenas
  • Lars Ernster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

Electron-transfer reactions as well as the generation and reactivity of free radicals in biological systems are controlled by thermodynamic-, kinetic-, and environmental factors1. The redox chemistry of hydro- and semi-quinones is in large extent determined by the physico-chemical properties of the molecule, such as the reduction potential and the influ- ence on it of the substitution pattern, by environmental factors, such as pH, solvent cage, solvation energy, and medium polarity, and by kinetic factors, which can allow a reaction -otherwise thermodynamically unlikely- to proceed by exerting a modification on its equilibrium.

Keywords

Superoxide Dismutase Quinoid Ring Solvent Cage Semiquinone Anion Radical Quinoid Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Enrique Cadenas
    • 1
    • 2
  • Lars Ernster
    • 1
    • 2
  1. 1.Department of Pathology IIUniversity of LinköpingLinköpingSweden
  2. 2.Department of BiochemistryUniversity of StockholmStockholmSweden

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