Improvement of Ischemic and Postischemic Mitochondrial Function by Deferrioxamine : The Role of Iron
Oxygen-derived free radicals have been implicated as a general mechanism of cell injury, including ischemia and reperfusion1,2. Superoxide anions and other reactive products of oxygen metabolism can be formed from subsequent intracellular reduction of oxygen, including hydrogen peroxide and the hydroxyl radical. However, in the myocardium and the mitochondria4 there exist a series of defence mechanisms to protect the cell against cytotoxic oxygen metabolites, which may be overwhelmed by an overproduction of oxygen free radicals.
KeywordsOxygen Free Radical Mitochondrial Oxidative Phosphorylation Myocardial Mitochondrion Krebs Henseleit Bicarbonate Buffer9 Cytosolic Iron
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