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Influence of Selenium on Lipid Peroxidation and Cardiac Functions in Chronically Adriamycin-Treated Rats

  • N. Koukay
  • S. Mouhieddine
  • M. J. Richard
  • J. Arnaud
  • J. De Leiris
  • A. Favier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

The Anthracycline antibiotic Adriamycin (Doxorubicin) is widely used in clinical medicine for cancer chemotherapy. Unfortunately, the clinical use of Adriamycin (ADR) is accompanied by side effects of which cardioto×icity is the most serious. The cumulative dose-dependent cardiomyopathy severely limits the total dose of ADR that can be administered in the treatment of neoplastic diseases(l). The prevention of ADR cardiotoxicity without interference with the drug’s antitumor activity would be of considerable advantage in achieving additional therapeutic benefit from this agent.

Keywords

Selenium Deficiency Selenium Intake Lipid Peroxidation Status Flow Rate Flow Rate Potential Dual Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • N. Koukay
    • 1
  • S. Mouhieddine
    • 2
  • M. J. Richard
    • 1
  • J. Arnaud
    • 1
  • J. De Leiris
    • 2
  • A. Favier
    • 1
  1. 1.Labo Biochimie CC.H.R.U.G.Grenoble CédexFrance
  2. 2.Labo. Physiologie Animale URA C.N.R.S. 632Université J. FourierGrenobleFrance

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