The Protective Role of Superoxide Dismutase During Activation of Ribonucleotide Reductase
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 264)
Ribonucleotide reductase (ribonucleoside diphosphate reductase, EC 220.127.116.11) is a key enzyme in the process of DNA synthesis, in all living cells1. It catalyzes and regulates the production of the four common deoxyribonucleotides, the precursors of DNA, from the corresponding ribonucleotides, the hydroxyl group at the 2’ position of the ribose moiety being substituted by a hydrogen atom.
KeywordsRibonucleotide Reductase Stable Free Radical Tyrosyl Radical Ribose Moiety Flavin Reductase
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© Plenum Press, New York 1990