The Protective Role of Superoxide Dismutase During Activation of Ribonucleotide Reductase

  • Marc Fontecave
  • Peter Reichard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Ribonucleotide reductase (ribonucleoside diphosphate reductase, EC is a key enzyme in the process of DNA synthesis, in all living cells1. It catalyzes and regulates the production of the four common deoxyribonucleotides, the precursors of DNA, from the corresponding ribonucleotides, the hydroxyl group at the 2’ position of the ribose moiety being substituted by a hydrogen atom.


Ribonucleotide Reductase Stable Free Radical Tyrosyl Radical Ribose Moiety Flavin Reductase 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Marc Fontecave
    • 1
  • Peter Reichard
    • 2
  1. 1.CNRS U.A. 400Université René DescartesParis Cedex 06France
  2. 2.Department of BiochemistryKarolinska InstituteStockholmSweden

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