Nuclear Glutathione Transferases which Detoxify Irradiated DNA
Free radicals have a number of toxic effects on the cell including the initiation of lipid peroxidation (Pryor, 1976) and the induction of potentially mutagenic lesions in DNA (Ames and Saul, 1986). Current knowledge suggests that some of the lesions in DNA may be peroxides. Irradiation of free thymidine gives a substantial yield of thymine hydroperoxides (Schulte Frohlinde and von Sonntag, 1985) and the incubation of irradiated DNA with GSH and tissue extracts containing GSH peroxidase activity brings about the catalytic oxidation of GSH to GSSG which is assumed to be due to the reduction of hydroperoxide moieties in DNA by GSH (Christopherson, 1969).
KeywordsGlutathione Transferase Fatty Acid Hydroperoxide Methyl Uracil Benzoquinone Imine Ethylene Dibromide
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