Antioxidative Properties of Met- and Leu-Enkephalin

  • Tanja Marotti
  • Višnja Šverko
  • Ivo Hršak
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Leukocytes have got receptors for opioid peptides and as such may be targets for immunomodulating activity by central neuroendocrine mechanisms (1). Opioid peptides alter adherence and chemotaxis of leukocytes (2). Phagocytosis by rat peritoneal macrophages was suppressed by Met-enkephalin (3). So far, Met- and Leu-enkephalin have been the most intensively studied opioid peptides. During phagocytosis, leukocytes experience a respiratory burst characterized by production of high levels of oxygen metabolites, such as Superoxide anion (O 2 - ) which results in highly toxic species that cause cell damage. We wanted, therefore, to examine whether Met- and Leuenkephalin affected Superoxide anion production of human polymorphonuclear neutrophils in vitro.


Respiratory Burst Opioid Peptide Hank Balance Salt Solution High Baseline Level Human Polymorphonuclear Leukocyte 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tanja Marotti
    • 1
  • Višnja Šverko
    • 1
  • Ivo Hršak
    • 1
  1. 1.Department of Experimental Biology and MedicineRuder Bošković InstituteZagrebYugoslavia

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