Reactive Oxygen Species Released by Human Blood Neutrophils Piroxicam-Treated Healthy Subjects

  • Marcelle Damon
  • Claude Chavis
  • Christian Le Doucen
  • Francis Blotman
  • A. Crastes de Paulet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


The polymorphonuclear neutrophils (PMNs) are known to be the major infiltrating phagocytes in the synovia of inflammatory joints in patients with rheumatoid arthritis. A continued extravasation of peripheral blood PMNs occurs to maintain the high local concentration of these cells (1). Therefore, it seems to be important to study the ability of these blood leucocytes to respond to various stimuli for a better understanding of the effects of anti-inflammatory drugs.


Phorbol Myristate Acetate Arachidonic Acid Metabolism High Local Concentration Arachidonic Acid Metabolite Lipoxygenase Pathway 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Marcelle Damon
    • 1
  • Claude Chavis
    • 1
  • Christian Le Doucen
    • 1
  • Francis Blotman
    • 2
  • A. Crastes de Paulet
    • 1
  1. 1.INSERM U 58France
  2. 2.Hôpital LapeyronieMontpellierFrance

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