Skip to main content
SpringerLink
Log in
Book cover

Antioxidants in Therapy and Preventive Medicine pp 261–264Cite as

Mechanism Whereby Different Anti-Oxidants and Lipoxigenase Pathway Inhibitors Suppress IL2 Synthesis

  • Chapter

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 264))

Abstract

It has been reported by several authors (1) and ourselves (2,3,4) that oxidatlve processes have been implicated in T cell responses. It wes found that several types of anti-oxidants suppressed T cell response, but that LO inhibitors display specific characteristics when compared to the other antioxidants.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. G. Chaudri, I.A.Clark, N.H.Hunt, W.B.Cowden, R.Ceredìg Effect of antioxidants on primary alloantigen-induced T cell activation and proliferation. J.lmmunol. 137:2646 (1986).

    Google Scholar 

  2. M.Serber, D.Ball, F.Michel, A.Crastes de Paulet. Mechanism of enhancing effect of irradiation on production of IL 2. Immunol.Lett. 9: 279.(1985)

    Article  Google Scholar 

  3. J.Dornand, C.Sekkat, J.C.Mani , M.Gerber Lipoxigenase inhibitors suppress IL2 synthesis: Relationship with [Ca+ + ] rise and the events Immunol.Lett. 16: 101(1987)

    Article  PubMed  CAS  Google Scholar 

  4. C.Sekkat, J.Dornand, M.Gerber Oxidative phenomena are implicated inhuman T cell stimulation .Immunology, 63: 431.(1988)

    PubMed  CAS  Google Scholar 

  5. S.Grinstein, S.Cohen, J.D.Goetz, A.Rothstein and E.W.Gelfand Characterisation of the activation of Na+/H+ exchange in lymphocytes by phorbolesters. Change in cytoplasmic pH dependence of the antiport. Proc. Natl. Acad.Sci. U.S.A 82: 1429.(1985)

    Article  PubMed  CAS  Google Scholar 

  6. M.Patarroyo, P.G.Beatty, J.W. Fabre and GahmbergC.S. Identification of a cell surface protein complex mediating phorbol ester-induced adhesion (binding) among human mononuclear leukocytes. Scand. J. Immunol. 22, 171.(1985)

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Biochimie des Membranes, Ecole de Chimie, CNRS, Rue de l’Ecole Normale, Montpellier, France

    Jacques Dornand

  2. Centre Paul Lamarque, INSERM, Montpellier, France

    Mariette Gerber

Authors
  1. Jacques Dornand
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mariette Gerber
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Centre National de la Recherche Scientifique, University of Paris, Paris, France

    Ingrid Emerit

  2. Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, California, 94720, USA

    Lester Packer

  3. Institut Gustave-Roussy, 94800, Villejuif, France

    Christian Auclair

  4. Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, 15, Rue de l’Ecole de Médecine, 75006, Paris, France

    Ingrid Emerit

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Plenum Press, New York

About this chapter

Cite this chapter

Dornand, J., Gerber, M. (1990). Mechanism Whereby Different Anti-Oxidants and Lipoxigenase Pathway Inhibitors Suppress IL2 Synthesis. In: Emerit, I., Packer, L., Auclair, C. (eds) Antioxidants in Therapy and Preventive Medicine. Advances in Experimental Medicine and Biology, vol 264. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5730-8_42

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5730-8_42

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5732-2

  • Online ISBN: 978-1-4684-5730-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation