Free Radical Scavenging Capacity and Anti-Inflammatory Activity of CBS-113 A
CBS-113 A, 2-(2-Hydroxy-4-methylphenyl)aminothiazole hydrochloride, is a dual inhibitor of cyclooxygenase and lipoxygenase with topical anti-inflammatory activity (1). This compound is also a powerful free radical (FR) scavenger. The aim of this study was to design a pharmacological model of ocular inflammation for determining the respective contribution of the FR scavenging capacity and the inhibition of icosanoid production to the anti-inflammatory activity of this compound.
KeywordsMigration Hydroxyl Carbohydrate DMSO Superoxide
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- 1.C. Coquelet and C. Bonne, CBS-113 A, Drugs of the Future 12:525 (1987).Google Scholar