Oxidative Damage in Chronic Heart Failure: Protection by Captopril Through Free Radical Scavenging?
The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in the plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.
KeywordsAngiotensin Converting Enzyme Chronic Heart Failure Chronic Heart Failure Patient Chronic Congestive Heart Failure Multicentre Research Group
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