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Sod in Rat Models of Shock and Organ Failure

  • Heinz Redl
  • Camille Lieners
  • Soheyl Bahrami
  • Günther Schlag
  • Ignaz P. T. van Bebber
  • R. Jan A. Goris
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

Posttraumatic or postoperative (multi) organ failure is the result of a multitude of reactions similar to (generalized) inflammatory situations. The fuel for this reaction cascade is either derived from continuous activation of humoral cascades (e.g. complement), continuous overshooting phagocytosis or toxic products of bacterial cells (e.g. endotoxin).

Keywords

Lipid Peroxidation Organ Failure Lipid Peroxidation Product Intestinal Ischemia Human Superoxide Dismutase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aebi, H., 1984, Catalase in vitro. Methods in enzymology, in:Oxygen Radicals in Biological Systems, L. Packer, ed., Academic Press, Orlando.Google Scholar
  2. Bahrami, S., Paul, E., Redl, H., and Schlag, G., 1989a, Therapeutic modalities to ameliorate endotoxin induced DIC in the rats, in:Progress in Clinical and Biological Research, Vol. 308: Second Vienna Shock Forum, G. Schlag, H. Redl, eds., Alan R. Liss Inc, New York, pp 977.Google Scholar
  3. Bahrami, S., Redl, H., Thurnher, M., Vogl, C., Paul, E., Schie/3er, A., and Schlag G., 1989b, Effect of PAF-antagonists in endotoxin shock -ovine and rat exerpiments, in:Progress in Clinical and Biological Research, Vol. 308: Second Vienna Shock Forum, G. Schlag, H. Redl, eds., Alan R. Liss Inc, New York, pp 931.Google Scholar
  4. Bahrami, S., Schießer, A., Redl, H., and Schlag, G., 1987, Comparison of different corticosteroids in rat endotoxemia, in:Progress in Clinical and Biological Research, First Vienne Shock Forum, Vol. 236-B: Monitoring and Treatment of Shock, G. Schlag, H. Redl, eds., Alan R. Liss, pp 237.Google Scholar
  5. Curzio, M., Esterbauer, H., DiMauro, C., Cecchini, G., and Dianzani, M., 1986, Chemotactic activity of lipid peroxidation product 4-hydroxynonenal and homologous hydroxyalkenals, Biol. Chem. Hoppe Seyler 367:321.PubMedCrossRefGoogle Scholar
  6. Deitch, E.A., Berg, R., and Specian R, 1987, Endotoxin promotes the translocation of bacteria from the gut, Arch. Surg. 122:185.Google Scholar
  7. Demling, R.H., Lalonde, C., Jin, L.J., Tyan, P., and Fox, R., 1986, Endotoxemia causes increased lung tissue lipid peroxidation in unanesthetized sheep, J. Appl. Physiol. 60:2094.PubMedGoogle Scholar
  8. Elstern, E.F., and Heupel, A., 1976, Inhibition of nitrite formation from hydroxylammoniumchloride: A simple assay for Superoxide dismutase, Anal. Biochem. 70:616.CrossRefGoogle Scholar
  9. Esterbauer, H., Koller, E., Slee, R.G., and Koster, J.F., 1986, Possible involvement of the lipid peroxidation product 4 hydroxy-nonenal in the formation of fluorescent chromolipids, Biochem. J. 239:405.PubMedGoogle Scholar
  10. Fine, J., Rutenburg, S.H., and Schweinburg F.R., 1959, The role of the RES in hemorrhagic shock, J. Exp. Med. 110:547.PubMedCrossRefGoogle Scholar
  11. Frei, B., Stocker, R., and Ames, B.N., 1988, Antioxidant defenses and lipid peroxidation in human blood plasma. Proc. Natl. Acad. Sci. USA 85:9748.PubMedCrossRefGoogle Scholar
  12. Goris, R.J.A., Boekholtz W.K.F., van Bebber, I.P.T., Nuytinck, J.K.S., and Schillings, P.H.M., 1986, Multiple organ failure and sepsis without bacteria, Arch. Surg. 121:897.Google Scholar
  13. Goris, R.J.A., te Boekhorst, T.P.A., Nuytinck, J.K.S., and Gimbrere, J.S.F. (1985), Multiple-organ failure. Generalized autodestructive inflammation? Arch. Surg. 120:1109.Google Scholar
  14. Granger, D.N., and Parks, D.A., 1983, Role of oxygen radicals in the pathogenesis of intestinal ischemia, Physiologist 26:159.PubMedGoogle Scholar
  15. Grisham, M.B., Hernandez , L.A., and Granger, D.N., 1986, Xanthine oxidase and neutrophils infiltration in intestinal ischemia, Am. J. Physiol. 251:G567.Google Scholar
  16. Kunimoto, F., Mlorita, T., Ogawa, R., and Fujita, T., 1987, Inhibition of lipid peroxidation improves survival rate of endotoxemic rats, Circ. Shock 21:15.Google Scholar
  17. Lieners, C.F.J., 1988, Lipidperoxidation -Analytik und Beeinflussung durch antioxidativ wirksame Enzyme, Dissertation, Technische Universität Wien.Google Scholar
  18. Lieners, C.F.J., Redl, H., Molnar, H., Fürst, W., Hallström, S., and Schlag, G., 1989, Lipidperoxidation in a canine model of hypo-volemic-traumatic shock, in:Progress in Clinical and Biological Research, Vol. 308: Second Vienna Shock Forum, G. Schlag, H. Redl, eds., Alan R. Liss Inc, New York, pp 345.Google Scholar
  19. Mangold, H.K., Bezzegh, T., 1984, Absorptimetric determination of total lipids in serum, according to Zöllner, Kirsch, in:Routine Methods of Lipids Analysis, Clinical Biochemistry, Principles and Methods, Vol. II, H.C. Curtius, M. Roth, eds., de Gruyter, Berlin. McCord, J.M., 1980, Oxygen free radicals: release and activities. A Superoxide activated chemotactic factor and its role in inflammatory processes. Agents Actions 10:522.Google Scholar
  20. McKechnie, K., Furman, B.L., and Parratt, J.R., 1986, Modification by oxygen freee radical scavengers of the metabolic and cardiovascular effects of endotoxin infusion in conscious rats, Circ. Shock 19: 429.Google Scholar
  21. Meakins, J.L., and Marshall, J.C., 1986, Multi-organ-failure syndrome. The gastrointestinal tract: the motor of MOF, Arch. Surg. 121: 196.Google Scholar
  22. Natale, J.E., Schott, R.J., Hall, E.D., Braughler, J.M., and D’Alecy L.G., 1989, The 21-aminosteroid U74006F reduces systemic lipid peroxidation, improves neurologic function, and reduces mortality after cardiopulmonary arrest in dogs, in:Progress in Clinical and Biological Research, Vol. 308: Second Vienna Shock Forum, G. Schlag, H. Redl, eds., Alan R. Liss Inc, New York, pp 891.Google Scholar
  23. Nerlich, M.L., Seidel, J., Regel, G., Nerlich, A.G., and Sturm, J.A., 1986), Klinisch experimentelle Untersuchungen zum oxidativen Membranschaden nach schwerem Trauma, Langenbecks Arch. Chir. Suppl: 217.Google Scholar
  24. Paubert-Braquet, M., Lavaud, P., Bellanger, L., Deby, C., and Guilbaud J., 1986, Depression of plasmatic tocopherol levels and plateletactivating factor (PAF)-induced platelet and polymorphonuclear leukocyte aggregation in burn-injured patients, in:Abstractbook Second Vienne Shock Forum, Vienna.Google Scholar
  25. Pretorius, J.P., Schlag, G., Redl, H., Botha, W.S., Goosen, D.J., Bosman, H., and van Eeden, A.F., 1987, The ’lung in shock’as a result of hypovolemic-traumatic shock in baboons, J. Trauma 27:1344.PubMedCrossRefGoogle Scholar
  26. Redl, H., and Schlag, G., 1989a, Humoral and cellular activation in blood leading to organ failure, in:First Wiggers-Bernard Conference on Shock, Sepsis, and Organ Failure, G. Schlag, H. Redl, eds., Alan R. Liss Inc., New York, in press.Google Scholar
  27. Redl, H., and Schlag, G., 1989b, Möglichkeiten der biochemischen Analytik im posttraumatischen und postoperativen Organversagen. Intensivmed., in press.Google Scholar
  28. Schlag, G., and Redl, H., 1986, Oxygen radicals in hypovolemic traumatic shock, in:Oxygen Free Radicals in Shock, G.P. Novelli, F. Ursini, eds., S. Karger, Basel.Google Scholar
  29. Schneider, J., Friderichs, E., and Giertz H., 1989, Protection by recombinant human Superoxide dismutase in lethal rat endotoxemia, in:Progress in Clinical and Biological Research, Vol. 308: Second Vienna Shock Forum, G. Schlag, H. Redl, eds., Alan R. Liss Inc, New York, pp 913.Google Scholar
  30. Till, G.O., and Ward, P.A., 1987, Oxygen radicals and lipid peroxidation in experimental shock, in:Progress in Clinical and Biological Research, First Vienna Shock Forum, Vol. 236-A: Pathophysiological Role of Mediators and Mediator Inhibitors in Shock, G. Schlag, H. Redl, eds., Alan R. Liss Inc, New York, pp 235.Google Scholar
  31. Van Bebber, I.P.T., Boekholtz, W.K.F., Goris, R.J.A., Schillings, P.H.M., Dinges, H.P., Bahrami, S., Redl, H., and Schlag, G., 1989, Neutrophil function and lipid peroxidation in a rat model of multiple organ failure, J. Surg. Res., in press.Google Scholar
  32. Wayner, D.D.M., Burton, G.W., Ingold, K.U., and Locke, S., 1985, Quantitative measurement of the total, peroxyl radical trapping antioxidant capability of human blood plasma by controlled peroxidation: the important contribution made by plasmaq proteins, Febs. Lett. 187:33.Google Scholar
  33. Wong, K., Cleland, L.G., and Poznansky, M.J., 1980, Enhanced antiinflammatory effect and reduced immunogenicity of bovine liver Superoxide dismutase by conjugation with homologous albumin, Agents Actions 10:231.PubMedCrossRefGoogle Scholar
  34. Yoshikawa, T., Murakami, M., Yoshida, N., Seto, O., and Kondo, M., 1983, Effects of Superoxide dismutase and catalase on disseminated intravascular coagultion in rats, Thromb. Haemost. 50:869.PubMedGoogle Scholar
  35. Younes, M., Schoenberg, M.H., Jung, H., Fredholm, B.B., Haglund, U., and Schildberg, F.W., (1984), Oxidative tissue damage following regional intestinal ischemia and reperfusion in the cat, Res. Exp. Med. 184:259.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Heinz Redl
    • 1
  • Camille Lieners
    • 1
  • Soheyl Bahrami
    • 1
  • Günther Schlag
    • 1
  • Ignaz P. T. van Bebber
    • 2
  • R. Jan A. Goris
    • 2
  1. 1.Ludwig Boltzmann Institute for Experimental and Clinical TraumatologyViennaAustria
  2. 2.Department of General Surgery St. RadboudUniversity HospitalNijmegenThe Netherlands

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