Antioxidant Properties of an Antiischaemic Agent : Trimetazidine

  • Pascale Clauser
  • Catherine Harpey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Trimetazidine (TMZ) has now been widely used throughout the world for more than ten years for the treatment of cellular manifestation of ischaemic disorders including coronary heart diseases, retinopathies and cochleo-vestibular diseases. Its efficacy has been assessed in double-blind studies versus placebo and versus reference drugs. In angina pectoris TMZ improves the patient’s condition in diminishing the number of daily attacks, assessed by the objective improvement of the exercise test : longer total duration (+ 18 %),. greater total work (+ 33 %) and delay in the 1 mm ST depression on the ECG which reflects a better tolerance to effort (Sellier, 1986). TMZ has also shown a very good tolerance and associated with other drugs, it allows to increase the therapeutical benefit (Brochier et al., 1986 ; Michaelides et al., 1987).


Electron Paramagnetic Resonance H202 Production Intracellular Acidosis Opsonize Zymosan Chick Embryonic Heart 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Pascale Clauser
    • 1
  • Catherine Harpey
    • 1
  1. 1.IRIS Neuilly sur SeineFrance

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