High Molecular Weight Forms of Deferoxamine: Novel Therapeutic Agents for Treatment of Iron-Mediated Tissue Injury
The iron chelator, deferoxamine (Desferal®), is presently used clinically for the treatment of acute and chronic iron toxicity. The chelator is an effective inhibitor of iron-catalyzed reactions leading to the formation of both oxygen and lipid-derived radicals. Deferoxamine (DFO) has been incorporated in a number of studies involving oxygen and lipid radical mediated reactions leading to tissue injury and has proven efficacious in ameliorating reperfusion injury.
KeywordsFerrous Sulfate Hydroxyethyl Starch Oral Iron High Molecular Weight Form Ferrous Gluconate
Unable to display preview. Download preview PDF.
- 5.G. Ambrosio, J. L. Zweier, W. E. Jacobus, M. L. Weisfeldt, and J. T. Flaherty, Improvement of postischemic myocardial function and metabolism induced by administration of defer oxamine at the time of reflow: The role of iron in the pathogenesis of reperfusion injury, Circulation 76:906 (1987).PubMedCrossRefGoogle Scholar
- 7.R. Bolli, B. S. Patel, W. X. Zhu, P. G. ONeill, M. L. Charlat, and R. Roberts, The iron chelator deferoxamine attenuates postischemic ventricular dysfunction, Am. J., Physiol. 253: H1372-H1380 (1987).Google Scholar
- 9.B. R. Reddy, R. A. Kloner, and K. Przyklenk, Early treatment with deferoxamine limits myocardial ischemia/reperfusion injury, Free Rad. Biol. Med., in press (1989).Google Scholar
- 11.S. Sanan, G. Sharma, R. Malhotra, D. P. Sanan, P. Jain and P. Vadhera: Protection by desferrioxamine against histopathological changes of the liver in the post-oligaemic of clini cal haemomorrhagic shock in dogs: Correlation with improved survival rate and recovery. Free Rad. Res. Commun. 6:29 (1989).CrossRefGoogle Scholar
- 12.C. F. Whitten, G. W. Gibson, M. H. Good, J. F. Goodwin, and A. J. Brough, Studies in acute iron poisoning. I. Desferrioxamine in the treatment of acute iron poisoning: Clinical observations, experimental studies, and theoretical considerations, Pediatrics 36:322 (1965).Google Scholar
- 17.P. E. Hallaway, J. W. Eaton, S. S. Panter, and B. E. Hedlund, Modulation of deferoxamine toxicity and clearance by covalent attachment to biocompatible polymers, Submitted for publication (1989).Google Scholar
- 20.E. Graf, J. R. Mahoney, Jr., J. R. Bryant, and J. W. Eaton, Iron-catalyzed hydroxyl radical formation: Stringent requirement for iron-coordinated water, J. Biol. Chem. 295:3620 (1984).Google Scholar