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Antioxidative Action of Zinc-Carnosine Compound Z-103

  • T. Tanigawa
  • T. Yoshikawa
  • Y. Naito
  • T. Yoneta
  • S. Ueda
  • H. Oyamada
  • T. Takemura
  • Y. Morita
  • K. Tainaka
  • N. Yoshida
  • S. Sugino
  • M. Kondo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

The objective of the present study was to examine the anti-free radical action of Z-103 in vitro. Z-103 is a novel synthetic compound of zinc and carnosine (β-alanyl-L-histidine) which has strong anti-ulcer action in many types of animal models.1Free radicals have come to considered to be playing a role in the pathogenesis of gastric mucosal injuries2,3. The antifree radical action of Z-103 were expected because zinc and carnosine have antioxidative properties4,5. To know its anti-free radical action in vitro will be significant to understand its mechanism of action as anti-ulcer drug.

Keywords

Lipid Peroxidation Electron Spin Resonance Xanthine Oxidase Ferrous Iron Electron Spin Resonance Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Refferences

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • T. Tanigawa
    • 1
  • T. Yoshikawa
    • 1
  • Y. Naito
    • 1
  • T. Yoneta
    • 1
  • S. Ueda
    • 1
  • H. Oyamada
    • 1
  • T. Takemura
    • 1
  • Y. Morita
    • 1
  • K. Tainaka
    • 1
  • N. Yoshida
    • 1
  • S. Sugino
    • 1
  • M. Kondo
    • 1
  1. 1.First Department of MedicineKyoto Prefectural University of MedicineKyoto, 602Japan

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