Sulfur Containing Compounds as Antioxidants

  • Patrick M. Dansette
  • Amor Sassi
  • Colette Deschamps
  • Daniel Mansuy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Several sulfur containing antioxidants have been used for therapeutic use as hepatoprotectors and radioprotectors. In particular the dithiolthione SULFARLEM, used as anticholestatic drug for more than 40 years, is shown to be antioxidant; preliminary pharmacokinetic data in man are presented, and hepatoprotective and radioprotective effect in mice are demonstrated.


Lipoic Acid Radioprotective Effect Paracetamol Poisoning Thiol Derivative Radioprotective Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    J. M. Williamson and A. Meister, Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate, Proc.Nat.Acad.Sci. USA. 78:936–9 (1981).PubMedCrossRefGoogle Scholar
  2. 2).
    B.H. Lauterburg, G. B. Corcoran and J.R. Mitchell, Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in the rats in vivo, J. Clin. Invest. 71:980–91 (1983).PubMedCrossRefGoogle Scholar
  3. 3).
    L.F. Prescott, R.N. Illingworth, J.A.J.H. Critchley, M.J. Stewart, R.D. Adam and A.T. Proudfoot, Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning,Brit. Med. J. 2:1087–1100 (1979).CrossRefGoogle Scholar
  4. 4).
    M.R. Landauer, H.D. Davis, J.A. Dominitz and JF. Weiss, Comparative behavioral toxicity of four sulhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine, Pharmacol. Ther., 39:97–100 (1988).PubMedCrossRefGoogle Scholar
  5. 5).
    M. Younes, C. Sause, C.P. Siegers, R. Lemoine, Effect of deferrioxamine and diethyldithiocarbamate on paracetamol-induced hepato-and nephrotoxicity.The role of lipid peroxidation, J. Appl. Toxicol. 8:261–5 (1988).PubMedCrossRefGoogle Scholar
  6. 6).
    P.R. Ryle and J.M. Dumont, Malotilate: The new hope for a clinically effective agent for the treatment of liver disease, Alcohol-Alcohol, 22:121–141 (1987).PubMedGoogle Scholar
  7. 7).
    A. Poeschl, D. Rehn, J.M. Dumont, P.K. Mueller and G. Hennings, Malotilate produces collagen synthesis and cell migration activity of fibroplast in vitro, Biochem.Pharmacol. 36:3957–63 (1987).PubMedCrossRefGoogle Scholar
  8. 8).
    S.S. Ansher, P. Dolan and E. Bueding, Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity, Hepatology 3:932–5 (1983).PubMedCrossRefGoogle Scholar
  9. 9).
    T.W. Kensler, P.A. Egner, M.A. Trush, E. Bueding and J.D. Groopman, Modification of aflatoxine Bl binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiolthione, Carcinogenesis 6:759–63 (1985).PubMedCrossRefGoogle Scholar
  10. 10).
    T.W. Kensler, P.A. Egner, P.M. Dolan, J.D. Groopman and B.D. Roebuck, Mechanism of protection against aflatoxin tumorigenicity in rats fed by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones, Cancer Res. 47:4272–7 (1987).Google Scholar
  11. 11).
    P. Talalay, M.J. Delong and H.J. Prochaska, Indentification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis, Proc. Nat. Acad. Sci. USA. 85:8261–5 (1988).PubMedCrossRefGoogle Scholar
  12. 12).
    D. Mansuy, A. Sassi, P.M. Dansette and M. Plat, A new potent inhibitor of lipid peroxidation in vitro and in vivo, the hepatoprotective drug anisyldithiolthione, Biochem. Biophys. Res. Commun. 135:1015–21 (1986).PubMedCrossRefGoogle Scholar
  13. 13).
    P.M. Dansette, A new potent inhibitor of lipid peroxidation in vitro and in vivo,the hepatoprotective drug anisyldithiolthione, in Local immunity: Tissue fibrosis;immune cells and mediators, J.P. Revillard and N. Wierzbicki,ed.,Fondation franco-allemande, Suresnes France, 3:203–208 (1987).Google Scholar
  14. 14).
    P. Dansette, A. Sassi, M. Plat, M.O. Christen and D. Mansuy, Strong inhibition of lipid peroxidation in vitro and in vivo by dithiolthione derivatives, in Drug metabolism from molecules to man, B.J. Benford, J.W. Bridges and G.G. Gibson, ed., Taylor and Francis, London, 755–9 (1987).Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Patrick M. Dansette
    • 1
  • Amor Sassi
    • 1
  • Colette Deschamps
    • 1
  • Daniel Mansuy
    • 1
  1. 1.Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Unité associée au CNRS en développement concerté avec l’INSERM, UA 400 CNRSUniversité René DescartesParis Cedex 06France

Personalised recommendations