Prostaglandins, Glutathione Metabolism, and Lipid Peroxidation in Relation to Inflammation in Bovine Mastitis

  • Faik Atroshi
  • Satu Sankari
  • Aldo Rizzo
  • Tuomas Westermarck
  • Jouko Parantainen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Bovine mastitis is an infectious disease causing inflammatory changes in the udder. Infection, inflammation and tissue injury are usually associated with lipid peroxidation and the formation of free radicals. We have studied the possible roles of some local tissue factors in mastitis. Among these, prostaglandins (PGs) are typical mediators of inflammation. The metabolism of glutathione (GSH) is in many ways involved in tissue protection particularly in limitation of excessive lipid peroxidation. GSH and GSH-enzymes like GSH-peroxidase (GSH-Px) are also closely involved in the metabolism of arachidonic acid to prostaglandins and other biologically active lipids.


Arachidonic Acid Somatic Cell Count Glutathione Metabolism Bovine Mastitis Tissue Protection 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Faik Atroshi
    • 1
  • Satu Sankari
    • 2
  • Aldo Rizzo
  • Tuomas Westermarck
    • 3
  • Jouko Parantainen
  1. 1.Dept. of Pharmacology & Toxic.College of Veterinary MedicineHelsinki SF 00550Finland
  2. 2.Dept. of Biochem.College of Veterinary MedicineHelsinki SFFinland
  3. 3.Helsinki Central Inst. Ment. Ret.KirkkonummiFinland

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