Prostaglandins, Glutathione Metabolism, and Lipid Peroxidation in Relation to Inflammation in Bovine Mastitis
Bovine mastitis is an infectious disease causing inflammatory changes in the udder. Infection, inflammation and tissue injury are usually associated with lipid peroxidation and the formation of free radicals. We have studied the possible roles of some local tissue factors in mastitis. Among these, prostaglandins (PGs) are typical mediators of inflammation. The metabolism of glutathione (GSH) is in many ways involved in tissue protection particularly in limitation of excessive lipid peroxidation. GSH and GSH-enzymes like GSH-peroxidase (GSH-Px) are also closely involved in the metabolism of arachidonic acid to prostaglandins and other biologically active lipids.
KeywordsArachidonic Acid Somatic Cell Count Glutathione Metabolism Bovine Mastitis Tissue Protection
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