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The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury

  • K. Grabitz
  • E. Freye
  • R. Prior
  • R. Kolvenbach
  • W. Sandmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

The incidence of postischemic paraparesis or paraplegia following thoracoabdominal aneurysm repair ranges between 4 and 30% (Crawford et al., 1986). Inspite numerous surgical techniques prolonged hypoxia of the lower parts of the spinal cord cannot always be avoided. Thus, application of pharmacological agents during ischemia and/or the reperfusion period for the reduction of spinal cord injury is appealing and has been the goal of numerous investigations (Faden et al., 1984; Lim et al., 1986; Oldfield et al., 1982) The following study was designed to evaluate the protective effect of the antioxidant Superoxide dismutase (SOD) in order to minimize the so called “reperfusion injury”. In the animal study spinal cord function was measured by somatosensory evoked potentials (SEP) in order to determine the effectiveness of therapy. Additionally, the neurological outcome and the hiostological findings were compared to a non treated group.

Keywords

Spinal Cord Spinal Cord Injury Spinal Cord Stimulation Somatosensory Evoke Potential Thoracoabdominal Aortic Aneurysm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • K. Grabitz
    • 1
  • E. Freye
    • 1
  • R. Prior
    • 2
  • R. Kolvenbach
    • 1
  • W. Sandmann
    • 1
  1. 1.Dept. of Vascular SurgeryHeinrich Heine UniversitätDüsseldorfGermany
  2. 2.Dept. of NeuropathologyHeinrich Heine UniversitätDüsseldorfGermany

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