The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury
The incidence of postischemic paraparesis or paraplegia following thoracoabdominal aneurysm repair ranges between 4 and 30% (Crawford et al., 1986). Inspite numerous surgical techniques prolonged hypoxia of the lower parts of the spinal cord cannot always be avoided. Thus, application of pharmacological agents during ischemia and/or the reperfusion period for the reduction of spinal cord injury is appealing and has been the goal of numerous investigations (Faden et al., 1984; Lim et al., 1986; Oldfield et al., 1982) The following study was designed to evaluate the protective effect of the antioxidant Superoxide dismutase (SOD) in order to minimize the so called “reperfusion injury”. In the animal study spinal cord function was measured by somatosensory evoked potentials (SEP) in order to determine the effectiveness of therapy. Additionally, the neurological outcome and the hiostological findings were compared to a non treated group.
KeywordsSpinal Cord Spinal Cord Injury Spinal Cord Stimulation Somatosensory Evoke Potential Thoracoabdominal Aortic Aneurysm
Unable to display preview. Download preview PDF.
- Crawford, E.S., Crawford, J.L., Safi, H.J., Coselli, J.S., Hess, K.R., Brooks, B., Norton, H.J. and Glaeser, D.H., 1986, Thoracoabdominal aortic aneurysms: Preoperative and intraoperative factors determining immediate and long-term results of operations in 605 patients. J Vasc Surg, 3: 389PubMedCrossRefGoogle Scholar
- Hess, M.L. and Manson, N.H., 1984, Molecular oxygen: Friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury. J Mol Cell Cardiol, 16: 969Google Scholar
- Laschinger, J.C., Cunningham, J.N., Cooper, M.M., Baumann, F:G., and Spencer, F.C., 1987, Monitoring of somatosensory evoked potentials during procedures on the thoracoabdominal aorta. J Thoracc Cardiovasc Surg, 94: 260Google Scholar
- Southorn, P., 1988, Free radicals in Medicine. Mayo Clinic Proceed, 63: 390Google Scholar
- Yatsu, F.M., 1987, Clinical aspects of reversible cerebral ischemia, in: Cerebral ischemia and hemorheology, Hartmann, Springer Verlag, Berlin, HeidelbergGoogle Scholar