Targeting Sod by Gene and Protein Engineering and Inhibition of Oxidative Stress in Various Diseases

  • Masayasu Inoue
  • Nobukazu Watanabe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


A large number of human-type enzymes and bioactive peptides has been produced by gene engineering technique. Based on molecular mechanisms for various diseases, some patients have been treated successfully with such recombinant enzymes and peptide hormones without immunological complications and nonspecific side effects. However, recent studies revealed that there are many cases in which such recombinant products failed to show therapeutic effect predominantly due to their unfavorable in vivo behavior. It should be noted that enzymes and bioactive peptides could have their metabolic impact only when sufficient amounts of these molecules were localized in appropriate compartments during the time required for metabolic modulation. Thus, targeting enzymes and bioactive peptides to their appropriate sites of action is prerequisite to normalize pathologic metabolism in a patient.


Plasma Half Life Bioactive Peptide Lethal Arrhythmia Reperfusion Arrhythmia Acute Gastric Mucosal Lesion 


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Masayasu Inoue
    • 1
  • Nobukazu Watanabe
    • 1
  1. 1.Department of BiochemistryKumamoto University Medical SchoolKumamoto 860Japan

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