Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase

  • Aalt Bast
  • Guido R. M. M. Haenen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Reduced glutathione (GSH) is known to play a pivotal role in the cellular oxidant defence system and is indispensable for preventing lipid peroxidation by free radicals and oxygen. In this respect several protective cytosolic and membrane bound enzymes have been described which utilize GSH as substrate or as cofactor. The respective contribution of each of these enzymes, like GSH S-transferases, selenium dependent GSH peroxidase and the selenium containing phospholipid hydroperoxide GSH peroxidase, to the oxidant defence has not been fully clarified yet1.


Lipid Peroxidation Lipoic Acid Microsomal Membrane Prevent Lipid Peroxidation Microsomal Lipid Peroxidation 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Aalt Bast
    • 1
  • Guido R. M. M. Haenen
    • 1
  1. 1.Department of Pharmacochemistry, Faculty of ChemistryVrije UniversiteitAmsterdamThe Netherlands

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