Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase
Reduced glutathione (GSH) is known to play a pivotal role in the cellular oxidant defence system and is indispensable for preventing lipid peroxidation by free radicals and oxygen. In this respect several protective cytosolic and membrane bound enzymes have been described which utilize GSH as substrate or as cofactor. The respective contribution of each of these enzymes, like GSH S-transferases, selenium dependent GSH peroxidase and the selenium containing phospholipid hydroperoxide GSH peroxidase, to the oxidant defence has not been fully clarified yet1.
KeywordsLipid Peroxidation Lipoic Acid Microsomal Membrane Prevent Lipid Peroxidation Microsomal Lipid Peroxidation
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- 3.L. A. Witting, Vitamin E and lipid antioxidants in free-radicals initiated reactions, in “Free Radicals in Biology Vol. IV”, W.A. Pryor, ed., Academic Press, New York (1980).Google Scholar
- 8.DJ. Kornburst and R.D. Mavis, Microsomal lipid peroxidation. Mol. Pharmacol. 17:400 (1980).Google Scholar
- 11.P.C. Jocelyn, “Biochemistry of the SH group”, Academic Press, New York -London (1972).Google Scholar