Vitamin E in Biological Systems

  • Lester Packer
  • Sharon Landvik
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Since the discovery of vitamin E over 50 years ago, its role in human health and its biological effectiveness have been under extensive research. It has been established that vitamin E deficiency states exist in humans in specific clinical situations. It is well accepted that vitamin E is the major 1ipid~soluble antioxidant in biological systems, protecting structures and functions of cell membranes from free radical damage. The impact of free radicals on the aging process and development of damage or disease and the protective role of vitamin E and other biological antioxidants in pre venting or delaying these processes is an area of active research.


Lipid Peroxidation Intermittent Claudication Alpha Tocopherol Dietary Vitamin Free Radical Damage 
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  1. 1.
    M.K. Horwitt, Interpretations of Requirements for Thiamin, Riboflavin, Niacin-Tryptophan, and Vitamin E Plus Comments on Balance Studies and Vitamin B6, Am J. Clin. Nutr. 44:973 (1986).PubMedGoogle Scholar
  2. 2.
    A. Van Gossum, et al., Decrease in Lipid Peroxidation Measured by-Breath Pentane Output in Normals after Oral Supplementation with Vitamin E, Clin. Nutr. 7:53 (1988).Google Scholar
  3. 3.
    S. Krishnamurthy, The Intriguing Biological Role of Vitamin E, J. Chem. Ed. 60:465 (1983).CrossRefGoogle Scholar
  4. 4.
    H. Wefers and H. Sies, The Protection by Ascorbate and Glutathione against Microsomal Lipid Peroxidation is Dependent on Vitamin E, Eur. J. Biochem. 174:353 (1988).PubMedCrossRefGoogle Scholar
  5. 5.
    J.G. Bieri, L. Corash, and V.S. Hubbard, Medical uses of Vitamin E, New Eng. J. Med. 308:1063 (1983).PubMedCrossRefGoogle Scholar
  6. 6.
    L.J. Machlin, Vitamin E, in: Handbook of Vitamins, L.J. Machlin, ed., Marcel Dekker, Inc., New York (1984).Google Scholar
  7. 7.
    D. Carpenter, Vitamin E Deficiency, Seminars in Neurol. 5:283 (1985).CrossRefGoogle Scholar
  8. 8.
    D.P.R. Muller, Vitamin, E-Its Role in Neurological Function, Postgrad. Med. J. 62:107 (1986).PubMedCrossRefGoogle Scholar
  9. 9.
    R.J. Sokol, Vitamin E Deficiency and Neurologic Disease, Ann. Rev. Nutr. 8:351 (1988).CrossRefGoogle Scholar
  10. 11.
    A.T. Diplock, Vitamin E, Selenium and Free Radicals, Med. Biol. 62:78 (1984).PubMedGoogle Scholar
  11. 12.
    G. A. Little, et al., Vitamin E and the Prevention of Retinopathy of Prematurity, Pediatrics 76:315 (1985).Google Scholar
  12. 13.
    M. Lemoyne, et al., Breath Pentane Analysis as an Index of Lipid Peroxidation: A Functional Test of Vitamin E Status, Am. J. Clin. Nutr. 46:267 (1987).PubMedGoogle Scholar
  13. 14.
    R. Lubrano, et al., Relationship between Red Blood Cell Lipid Peroxidation, Plasma Hemoglobin, and Red Blood Cell Osmotic Resis tance before and after Vitamin E Supplementation in Hemodialysis Patients, Artif. Organs 10:245 (1986).PubMedCrossRefGoogle Scholar
  14. 15.
    K. A. Pritchard, et al., Triglyceride-Lowering Effect of Dietary Vitamin E in Streptozocin-Induced Diabetic Rats, Diabetes 35:278 (1986).PubMedCrossRefGoogle Scholar
  15. 16.
    M.M.B. Kay, et al., Oxidation as a Possible Mechanism of Cellular Aging: Vitamin E Deficiency Causes Premature Aging and IgG Binding to Erythrocytes, Proc. Natl. Acad. Sci. 83:2463 (1986).PubMedCrossRefGoogle Scholar
  16. 17.
    M. Meydani, C.P. Verdon, and J.B. Blumberg, Effect of Vitamin E, Selenium and Age on Lipid Peroxidation Events in Rat Cerebrum, Nutr. Res. 5:1227 (1985).Google Scholar
  17. 18.
    M. Meydani, J.B. Macauley and J.B. Blumberg, Influence of Dietary Vitamin E, Selenium and Age on Regional Distribution of Alpha Tocopherol in the Rat Brain, Lipids 21:786 (1986).Google Scholar
  18. 19.
    M. Wartanowicz, et al., The Effect of Alpha Tocopherol and Ascorbic Acid on the Serum Lipid Peroxide Level in Elderly People, Ann. Nutr. Metab. 28:186 (1984).CrossRefGoogle Scholar
  19. 20.
    D. Harman, Free Radical Theory of Aging: The Free Radical Diseases, Age 7:111 (1984).CrossRefGoogle Scholar
  20. 21.
    K.N. Prasad and J. Edwards-Prasad, Effects of Tocopherol (Vitamin E) Acid Succinate on Morphological Alterations and Growth Inhibition in Melanoma Cells in Culture, Cancer Res. 42:550 (1982).PubMedGoogle Scholar
  21. 22.
    C. Borek, et al., Selenium and Vitamin E Inhibit Radiogenic and Chemically Induced Transformation in Vitro via Different Mechanisms, Proc. Natl. Acad. Sci. 83: 1490 (1986).PubMedCrossRefGoogle Scholar
  22. 23.
    S.R. Tannenbaum and W. Mergens, Reaction of Nitrite with Vitamins C and E, Ann. N.Y. Acad. Sci. 355:267 (1980).PubMedCrossRefGoogle Scholar
  23. 24.
    M.G. Cook and P. McNamara, Effect of Dietary Vitamin E on Dimethyl-hydrazine-Induced Colonic Tumors in Mice, Cancer Res. 40:1329 (1980).PubMedGoogle Scholar
  24. 25.
    O. Odukoya, F. Hawach, and G. Shklar, Retardation of Experimental Oral Cancer by Topical Vitamin E, Nutr. Cancer 6:98 (1984).PubMedCrossRefGoogle Scholar
  25. 26.
    G. Shklar, Oral Mucosal Carcinogenesis in Hamsters: Inhibition by Vitamin E, JNCI 68:791 (1982).PubMedGoogle Scholar
  26. 27.
    P.M. Horvath and C. Ip, Synergistic Effect of Vitamin E and Selenium in the Chemoprevention of Mammary Carcinogenesis in Rats, Cancer-Res. 43:5335 (1983).PubMedGoogle Scholar
  27. 28.
    J.T. Salonen, et al., Risk of Cancer in Relation to Serum Concentrations of Selenium and Vitamins A and E: Matched Case Control Analysis of Prospective Data, Brit. Med. J. 290:417 (1985).CrossRefGoogle Scholar
  28. 29.
    P. Knekt, et al., Serum Vitamin E and Risk of Cancer among Finnish Men during a Ten-Year Follow-up, Am. J. Epidemiol. 127:28 (1988).PubMedGoogle Scholar
  29. 30.
    H.B. Stahelin, et al., Cancer, Vitamins and Plasma Lipids: Prospective Basel Study, JNCI 73:1463 (1984).PubMedGoogle Scholar
  30. 31.
    F.J. Kok, et al., Micronutrients and the Risk of Lung Cancer, New Eng. J. Med. 316:1416 (1987).Google Scholar
  31. 32.
    M.S. Menkes, et al., Serum Beta-Carotene, Vitamins A and E, Selenium and the Risk of Lung Cancer, New Eng. J. Med. 315:1250 (1986).PubMedCrossRefGoogle Scholar
  32. 33.
    T. Yoshikawa, H. Tanaka, and M. Kondo, Effect of Vitamin E on Adjuvant Arthritis in Rats, Biochem. Med. 29:227 (1983).PubMedCrossRefGoogle Scholar
  33. 31.
    M. Mezes and G. Bartosiewicz, Investigations on Vitamin E and Lipid Peroxide Status in Rheumatic Diseases, Clin. Rheumatol. 2:259 (1983).PubMedCrossRefGoogle Scholar
  34. 35.
    D. Rowley, et al., Lipid Peroxidation in Rheumatoid Arthritis: Thiobarbituric Acid-Reactive Material and Catalytic Iron Salts in Synovial Fluid from Rheumatoid Patients, Clin. Sci. 66:691 (1981).Google Scholar
  35. 36.
    T. Yoshikawa, et al, Influence of Vitamin E on Rat Adjuvant Arthritis, Jap. J. Inflam. 2:116 (1982).Google Scholar
  36. 37.
    I. Machtey and L. Ouaknine, Tocopherol in Osteoarthritis: A Controlled Pilot Study, J. Am. Ger. Soc. 26:328 (1978).Google Scholar
  37. 38.
    G. Blankenhorn, Clinical Efficacy of Spondyvit (Vitamin E) in Activated Arthroses, Z. Orthop. 21:310 (1986).Google Scholar
  38. 39.
    M.A.-Boogaerts, et al., Protective Effect of Vitamin E on Immune Triggered, Granulocyte Mediated Endothelial Injury, Thromb. Haemostas (Stuttgart) 51:89 (1981).Google Scholar
  39. 10.
    K.C. Srivastava, Vitamin E Exerts Antiaggregatory Effects without Inhibiting the Enzymes of the Arachidonic Acid Cascade in Platelets, Prostagland. Leukotrienes Med. 21:177 (1986).CrossRefGoogle Scholar
  40. 11.
    C.W. Karpen, et al., Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat-Influence of Dietary Vitamin E, Diabetes 31:9l7 (1982).Google Scholar
  41. 12.
    M. Ciavatti, et al., Vitamin E Prevents the Platelet Abnormalities Induced by Estrogen in Rats, Contraception 30:279 (1981).CrossRefGoogle Scholar
  42. 13.
    G.H. Mclntosh, et al., The Influence of Linoleate and Vitamin E from Sunflower Seed Oil on Platelet Function and Prostaglandin Production in the Common Marmoset Monkey, J. Nutr. Sci. Vitaminol. 33:299 (1987).CrossRefGoogle Scholar
  43. 11.
    A. Szczeklik, et al., Dietary Supplementation with Vitamin E in Hyperlipoproteinemias: Effects on Plasma Lipid Peroxides, Antioxidant Activity, Prostacyclin Generation and Platelet Aggregability, Thromb. Haemostas (Stuttgart) 51:125 (1985).Google Scholar
  44. 15.
    M. Steiner, Effect of Alpha Tocopherol Administration on Platelet Function in Man, Thromb. Haemostas (Stuttgart) 19:73 (1983).Google Scholar
  45. 16.
    C.W. Karpen, et al., Production of 12-Hydroxyeicosatetraenoic Acid and Vitamin E Status in Platelets from Type I Human Diabetic Subjects, Diabetes 31:526 (1985).CrossRefGoogle Scholar
  46. 17.
    C.W. Karpen, et al., Interrelation of Platelet Vitamin E and Thromboxane Synthesis in Type I Diabetes Mellitus, Diabetes 33:239 (1981).CrossRefGoogle Scholar
  47. 18.
    M. Steiner, Effect of Vitamin E on Platelet Function and Thrombosis, Agents and Actions 22:357 (1987).CrossRefGoogle Scholar
  48. 19.
    S. Renaud, et al., Influence of Vitamin E Administration on PlateletFunctions in Hormonal Contraceptive Users, Contraception 36:317 (1987).CrossRefGoogle Scholar
  49. 50.
    M.J. Pinsky, Treatment of Intermittent Claudication with Alpha Tocopherol, J. Am. Podiatry Assoc. 70:151 (1980).Google Scholar
  50. 51.
    K. Haeger, Walking Distance and Arterial Flow during Long Term Treatment of Intermittent Claudication with d-Alpha Tocopherol, J. Vasc. Dis. 2:280 (1973).Google Scholar
  51. 52.
    K. Haeger, Long Time Treatment of Intermittent Claudication with Vitamin E, Am. J. Clin. Nutr. 27:1179 (1974).PubMedGoogle Scholar
  52. 53.
    K. Haeger, Long Term Study of Alpha Tocopherol in Intermittent Claudication, Ann. N.Y. Acad. Sci. 393:369 (1982).PubMedCrossRefGoogle Scholar
  53. 51.
    S. Marubayashi, et al., Role of Free Radicals in Ischemic Rat Liver Cell Injury: Prevention of Damage by Alpha Tocopherol Administra tion, Surgery 99:181 (1986).Google Scholar
  54. 55.
    M. Yamamoto, et al., A Possible Role of Lipid Peroxidation in Cellular Damages caused by Cerebral Ischemia and the Protective Effect of Alpha Tocopherol Administration, Stroke 11:977 (1983).CrossRefGoogle Scholar
  55. 56.
    S. Yoshida, et al., Influence of Transient Ischemia on Lipid-Soluble Antioxidants, Free Fatty Acids and Energy Metabolites in Rat Brain, Brain Res. 245:307 (1982).Google Scholar
  56. 57.
    S. Fujimoto, et al., The Protective Effect of Vitamin E on Cerebral Ischemia, Surg. Neurol. 22:449 (1984).PubMedCrossRefGoogle Scholar
  57. 59.
    W.M. Ross, et al., Radiation Cataract Formation Diminished by Vitamin E in Rat Lenses in Vitro, Exp. Eye Res. 36:645 (1983).PubMedCrossRefGoogle Scholar
  58. 60.
    J.R. Trevithick, et al., Modelling Cortical Cataractogenesis: 2. In Vitro Effects on the Lens of Agents Preventing Glucose-and Sorbitol-Induced Cataracts, Can. J. Ophthalmol. 16:32 (1981).PubMedGoogle Scholar
  59. 61.
    M.O. Creighton, et al., Modelling Cortical Cataractogenesis. VII. Effects of Vitamin E Treatment on Galactose-Induced Cataracts, Exp. Eye Res. 40:213 (1985).PubMedCrossRefGoogle Scholar
  60. 62.
    W.M. Ross, et al., Modelling Cortical Cataractogenesis: 3. In Vivo Effects of Vitamin E on Cataractogenesis in Diabetic Rats, Can. J. Ophthalmol. 17:61 (1982).Google Scholar
  61. 63.
    P.F. Jacques, et al., Antioxidant Status in Persons with and without Senile Cataract, Arch. Ophthalmol. 106:337 (1988).PubMedCrossRefGoogle Scholar
  62. 64.
    L. Packer, Vitamin E, Physical Exercise and Tissue Damage in Animals, Med. Biol. 62:105 (1984).PubMedGoogle Scholar
  63. 65.
    K.J.A. Davies, A.T. Quintanilha, G.A. Brooks and L. Packer, Free Radicals and Tissue Damage Produced by Exercise, Biochem. Biophys. Res. Commun. 107:1198 (1982).PubMedCrossRefGoogle Scholar
  64. 66.
    K.M. Aikawa, A.T. Quintanilha, B.O. de Lumen, G.A. Brooks and L. Packer, Exercise Endurance Training Alters Vitamin E Tissue Levels and Red-Blood-Cell Hemolysis in Rodents, Biosci. Rep. 4:253 (1984).Google Scholar
  65. 67.
    K. Gohil, L. Rothfuss, J. Lang and L. Packer, Effect of Exercise Training on Tissue Vitamin E and Ubiquinone Content, J. Appl. Physiol. 63:1638 (1987).PubMedGoogle Scholar
  66. 68.
    K. Gohil, L. Packer, B.O. de Lumen, G.A. Brooks and S.E. Terblanche, Vitamin E Deficiency and Vitamin C Supplements: Exercise and Mitochondrial Oxidation, J. Appl. Physiol. 60:1986 (1986).PubMedGoogle Scholar
  67. 69.
    C.J. Dillard, et al., Effects of Exercise, Vitamin E, and Ozone on Pulmonary Function and Lipid Peroxidation, J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 45:927 (1978).Google Scholar
  68. 70.
    I. Simon-Schnass and H. Pabst, Influence of Vitamin E on Physical Performance, Internat. J. Vit. Nutr. Res. 58:49 (1988).Google Scholar
  69. 71.
    A. Sevanian, A.D. Hacker, and N. Elsayed, Influence of Vitamin E and Nitrogen Dioxide on Lipid Peroxidation in Rat Lung and Liver Microsomes, Lipids 17:269 (1982).PubMedCrossRefGoogle Scholar
  70. 72.
    D.P. Franco and S.G. Jenkinson, Rat Lung Microsomal Lipid Peroxidation: Effects of Vitamin E and Reduced Glutathione, J. Appl. Physiol. 61:785 (1986).PubMedGoogle Scholar
  71. 73.
    C.K. Chow, et al, Dietary Vitamin E and Pulmonary Biochemical and Morphological Alterations of Rats Exposed to 0.1 ppm Ozone, Environ. Res. 24:315 (1981).CrossRefGoogle Scholar
  72. 74.
    C.K. Chow, et al., Dietary Vitamin E and Pulmonary Biochemical Responses of Rats to Cigarette Smoking. Environ. Res. 34:8 (1984).PubMedCrossRefGoogle Scholar
  73. 75.
    E.R. Pacht, et el., Deficiency of Vitamin E in the Alveolar Fluid of Cigarette Smokers, J. Clin. Invest. 77:789 (1986).PubMedCrossRefGoogle Scholar
  74. 76.
    R. Shariff, et al., Vitamin E Supplementation in Smokers, Am. J. Clin. Nutr. 47:758 (1988).Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Lester Packer
    • 1
  • Sharon Landvik
    • 1
  1. 1.Department of Physiology-AnatomyUniversity of CaliforniaBerkeleyUSA

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