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Radiation Recovery Agents: Cu(II), Mn(II), Zn(II), OR Fe(III) 3,5-Diisopropylsalicylate Complexes Facilitate Recovery from Ionizing Radiation Induced Radical Mediated Tissue Damage

  • John J. R. Sorenson
  • Lee S. F. Soderberg
  • Max L. Baker
  • John B. Barnett
  • Louis W. Chang
  • Hamid Salari
  • William M. Willngham
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

Pathological consequences of human exposure to increasing doses of ionizing radiation: Hematopoietic, Gastrointestinal, and Central Nervous System syndromes, are rather well understood.1 Bone marrow aplasia and loss of immunocompetency with low (2 to 10 Gray) doses of irradiation, gastrointestinal ulceration and systemic infection with higher radiation doses, and loss of brain function with still higher doses account for the diminishing duration of survival following exposure to increasing doses of ionizing radiation.

Keywords

Irradiate Mouse Bone Marrow Aplasia Acute Radiation Syndrome Central Nervous System Syndrome Lymphoid Follicle Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • John J. R. Sorenson
    • 1
  • Lee S. F. Soderberg
    • 2
  • Max L. Baker
    • 3
  • John B. Barnett
    • 2
  • Louis W. Chang
    • 4
  • Hamid Salari
    • 1
  • William M. Willngham
    • 5
  1. 1.Division of Medicinal Chemistry, Department of Biopharmaceutical Sciences, College of PharmacyUniversity of Arkansas for Medical SciencesLittle RockUSA
  2. 2.Department of Microbiology, and Immunology, College of MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA
  3. 3.Department of Radiology, College of MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA
  4. 4.Department of Pathology, College of MedicineUniversity of Arkansas for Medical SciencesLittle RockUSA
  5. 5.Chemistry DepartmentUniversity of Arkansas at Pine BluffPine BluffUSA

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