Muscarinic Receptors, Phosphoinositide Hydrolysis, and Neuronal Plasticity in the Hippocampus

  • Fulton T. Crews
  • Norbert J. Pontzer
  • L. Judson Chandler
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)


Previous studies have suggested that muscarinic cholinergic receptors in the hippocampus are associated with memory processes. Antimuscarinic drugs, well known for their amnestic effects, support the cholinergic hypothesis of memory (Bartus et al„ 1982). Several biochemical and electrophysiological responses to muscarinic agonist stimulation have been described in the hippocampus, including reduction of a calcium-dependent potassium current (IKca) that is responsible for after-hyperpolarization (AHP) (Bernado and Prince, 1982), reduction of a time- and voltage-dependent non-inactivating potassium current termed the M-current (IKm) (Halliwell and Adams, 1982), inhibition of cyclic-AMP (Olianas et al., 1983), stimulation of cyclic-GMP (Snyder et al., 1984), and stimulation of phosphoinositide (PI) turnover (Gonzales and Crews, 1985; Fisher and Bartus, 1985). This multiplicity of responses has obscured the relationship between biochemical and electrophysiological responses to muscarinic agonists. In addition, the relationship between muscarinic action on specific membrane ionic conductances, especially IKm, and neuronal action potential generation, is not clear.


Firing Rate Muscarinic Receptor Phorbol Ester Full Agonist Muscarinic Agonist 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Fulton T. Crews
    • 1
  • Norbert J. Pontzer
    • 1
  • L. Judson Chandler
    • 1
  1. 1.Department of Pharmacology and TherapeuticsUniversity of Florida College of Medicine, J.H. Miller Health CenterGainesvilleUSA

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