Postmortem Stability of RNA Metabolism in Human Brain: Studies of the Nondemented Control and Alzheimer’s Disease Cases

  • E. M. Sajdel-Sulkowska
  • H. J. Manz
  • C. A. Marotta
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)


Neurochemical analyses of postmortem human brain tissue is currently a challenging and expanding area of research. Many studies are utilizing the autopsied brain material to probe the molecular mechanism of neurological and psychiatric diseases that are uniquely human and for which adequate animal models have not been developed. Despite a logical misconception, the degeneration of some of the cellular structures, enzyme activities, and macromolecules occurs gradually in human brain. Since a number of enzymatic activities are preserved during a period up to 24 hours, there is sufficient time to carry out routine handling of autopsy material as well as specialized procedures. Preservation of specific structures and functions allows for direct examination of molecular changes that are characteristic of the normal human aging process and changes that are unique to pathological conditions such as Alzheimer’s disease.


Glial Fibrillary Acidic Protein Postmortem Human Brain Uridine Incorporation Postmortem Human Brain Tissue Postmortem Alzheimer Brain 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • E. M. Sajdel-Sulkowska
    • 1
    • 2
    • 3
    • 4
  • H. J. Manz
    • 1
    • 2
    • 3
    • 4
  • C. A. Marotta
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of PsychiatryHarvard Medical SchoolUSA
  2. 2.Mailman Research CenterMcLean Hospital, BelmontUSA
  3. 3.Georgetown University School of MedicineUSA
  4. 4.Neurobiology LaboratoryMassachusetts General Hospital, BostonUSA

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