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NMDA Receptors, Aging and Alzheimer’s Disease

  • Kevin J. Anderson
  • Daniel T. Monaghan
  • James W. Geddes
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)

Abstract

Much research on the aging of the brain has been devoted in recent years to the possible alterations in specific neurotransmitter systems and the receptors which subserve neural transmission. This emphasis on transmitter systems is the result of the availability of new and specific ligands to probe receptor numbers and function as well as highly sensitive assays to directly measure transmitter content. The possibility that breakdowns in individual transmitter systems may correlate with specific clinical symptoms in aging-related disease has received much support, and indeed is well demonstrated in the dopaminergic dysfunction of Parkinson’s disease, and, to a lesser extent, the cholinergic deficits seen in Alzheimer’s disease (AD). However, it is not well understood how changes in transmitter systems during the course of “normal” aging affect brain function.

Keywords

NMDA Receptor Entorhinal Cortex Excitatory Amino Acid Aged Brain Excitatory Amino Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Kevin J. Anderson
    • 1
  • Daniel T. Monaghan
    • 2
  • James W. Geddes
    • 2
  1. 1.Departments of Physiological Sciences and NeuroscienceUniversity of FloridaGainesvilleUSA
  2. 2.Department of SurgeryUniversity of CaliforniaIrvineUSA

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