The Effects of Nucleus Basalis Lesions in the Rat on One Way Passive and Active Avoidance, Two Way Avoidance, and Lashly III Maze Learning: An Animal Model for SDAT
- 1.The choice of an appropriate organism. In choosing a candidate organism the following issues should be addressed.
Are there well established neurological homologies between the model’s CNS and the human CNS?
Is the model organism’s behavior well enough studied and described so that pathologies in behavior due to disease or lesions have an adequate research base for comparison to normal behavior?
Is the organism’s behavior homologous to a wide variety of human behavior?
Is it practical and cost efficient to use a given organism?
- 2.Once the organism has been selected, the choice of the behaviors to be studied must have a rational basis. Although this seems obvious, there are subtle nuances often overlooked. When an investigator decides that one way passive avoidance would be a good test for memory function many questions must be answered, such as:Variations in these parameters can lead to a wide variety of interpretations of findings. Furthermore, analysis of the data is often simplistic (such as only measuring latency of entering the shock chamber in one way passive avoidance) when a more sophisticated description and analysis of behavior would lead to more insights into the behavioral deficit. One of the goals of the research to be reported on in this chapter was to achieve a finer analysis of the avoidance behavior often used in research in Alzheimer’s disease using various animal models.
Number of pre-shock trials
Number of shock trials
Intensity of shock
Number of spacing of post shock trials
Another important decision is the use of inter-subject designs as opposed to intra-subject designs. By this we mean using different animals for each behavior investigated (inter-subject) or exposing each animal to a wide variety of tasks (intra-subject). While the former has the appeal of noncontamination of one behavior by previous experiences (use of the so called naive subject) it suffers in generalizing to human behavior since humans, and all higher organisms, have a rich variety of experiences against which pathological changes must be assessed. Furthermore, intra-subject designs are more efficient because more information is obtained per subject. Balanced against the above advantages of the intra-subject design is the necessity of determining the order of behaviors to be investigated or the controlling of them through counterbalancing procedures.
KeywordsCage Dementia Beach Expense Pentobarbital
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- 3.Boice, R. (1973) Domestication. Psychological Bulletin 80: 215230.Google Scholar
- 5.Bowen, D., Sims, N., Benton, J., Curzon, G., Davison, A., Neary, D., and Thomas, D. (1981) Treatment of Alzheimer’s disease: A cautionary Note. New England Jsiprnal of Medicine 305: 1016.Google Scholar
- 11.Hepler, D.J., Olton, D.S., Wenk, G.L., and Coyle, J.T. (1985) Lesions ion the nucleus basalis magnocellularis and medial septal area of rats produce qualitatively similar memory impairments. Journal of Neuroscience 5: 866–873.Google Scholar
- 17.Araki, H., Lichiyama, Y., Kawashima, K., and Aihara, H. (1986) Impairment in memory and changes in neurotransmitters induced by basal forebrain lesions in rats.,Tappan Journal of Pharmacology41: 497–504.Google Scholar
- 19.Issacson, R.L. and Wicklegrn, W.O. (1962) Hippocampal ablation and passive avoidance. Science 138: 1104–1106.Google Scholar
- 20.Blanchard, R.J. and Blanchard, D.C. (1972). Effects of hippocampal lesions on the rat’s reaction to a cat.,Journal of Comparative and Physiological Psychology 78: 77–82.Google Scholar
- 22.Issacson, R.L., Douglas, R.J., and Moore, R.Y. (1961) The effect of radical hippocampal ablation on acquisition of avoidance responses. Journal of Comparative and Physiological Psvcholoci 54: 625–628.Google Scholar
- 26.Arendash, G., Strong, P., and Mouton, P. (1985) Intercerebral transplants of cholinergic neurons in a new animal model for Alzheimer’s disease. In: Senile Dementia of the Alzheimer’s Type, (eds. Hutton, J. and Kenny, A.) Alan R. Liss, Inc. New York, pp 351–376.Google Scholar
- 27.Olton, D.S. (1983) The use of animal models to evaluate the effects of neurotoxins on cognitive processes. Behavioral Toxicology and Teratology 5: 635–640.Google Scholar