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Development of a Pyrrolidinone Derivative (Cyclic GABA) for Modulating Brain Glutamate Transmission

  • Kenji Matsuyama
  • Choichiro Miyazaki
  • Masataka Ichikawa
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)

Abstract

Senile Dementia of Alzheimer Type (SDAT) is a debilitating neurological disease that affects about one in six persons past the age of sixty (1,2). In spite of numerous hypotheses concerning the etiology of SDAT, e.g., abnormal blood aluminum levels (3), viral agents (4), genetic factors (5) and selective vulnerability of specific neuronal systems (6,7), its precise cause or causes remain unknown.

Keywords

Passive Avoidance Gaba Level Shadowed Area Passive Avoidance Response Brain Gaba 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Kenji Matsuyama
    • 1
  • Choichiro Miyazaki
    • 1
  • Masataka Ichikawa
    • 1
  1. 1.Department of Hospital PharmacyNagasaki University HospitalNagasaki 852Japan

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