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Brain-Enhanced Delivery of Anti-Dementia Drugs

  • Marcus E. Brewster
  • Cynthia Robledo-Luiggi
  • Akio Miyakeb
  • Emil Pop
  • Nicholas Bodor
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)

Abstract

Senile dementia of the Alzheimer’s type (SDAT) is a slowly progressive neurological disorder which is characterized by severe and debilitating memory loss. This insidious and pernicious malady is expected to strike 20% of all individuals over the age of eighty (Bartus et al., 1982), an important and growing demographic block. At present the etiological basis of SDAT is unknown and work has been aimed at palliative treatments to increase the quality of life of those individuals stricken with the disease. In SDAT, numerous biochemical/physiological observations have suggested that a cholinergic deficit is in some way related to the disease (Becker and Giacobini, 1988 and references cited therein). Such evidence includes selective degeneration of cholinergic neurons in the basal forebrain, decreased activity and concentration of acetyl choline (ACh), choline acetyltransferase, the enzyme responsible for synthesizing ACh and acetyl cholinesterase (AChE), the enzyme responsible for ACh degradation (Sims et al., 1983). Given this biochemical basis for dementia, therapeutic approach have concentrated on bolstering the impaired cholinergic system either by agonist administration (Corkin, 1981) or by developments of AChE inhibitors. Compounds resulting from the latter scheme have offered the most potential in SDAT and include physostigmine, aminopyridines and 9amino-1,2,3,4-tetrahydroacridine (THA).

Keywords

High Performance Liquid Chromatography Methyl Iodide Sodium Dithionite Quaternary Salt Pyridinium Salt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Marcus E. Brewster
    • 1
  • Cynthia Robledo-Luiggi
    • 1
  • Akio Miyakeb
    • 1
  • Emil Pop
    • 1
  • Nicholas Bodor
    • 1
  1. 1.Center for Drug Design and Delivery, College of PharmacyUniversity of FloridaGainesvilleUSA

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