Growth Factor and Lymphokine Effects on Brain Cholinergic Systems

  • Dalia M. Araujo
  • Paul A. Lapchak
  • Jean-Guy Chabot
  • Remi Quirion
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)


The localization of various growth factors (GFs) and lymphokines in the mammalian brain (1) has expanded the list of possible roles for these substances. The identification of specific binding sites for GFs such as nerve GF (NGF), epidermal GF(EGF), and the insulin-like GFs (IGF-1 and IGF-2) (2), and for IL-1 (3–5), on cells of glial and neuronal origin have underlined further the importance of GFs and ILs in the mammalian CNS. However, the precise function of these substances in the brain has not been completely elucidated.


Nerve Growth Factor Hippocampal Slice Brain Cholinergic System Epidermal Growth Factor Receptor Immunoreactivity Hippocampus Striatum Cortex 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Dalia M. Araujo
    • 1
  • Paul A. Lapchak
    • 2
  • Jean-Guy Chabot
    • 1
  • Remi Quirion
    • 1
  1. 1.Douglas Hospital Research Center and Dept. of PsychiatryMcGill UniversityMontrealCanada
  2. 2.Neuroanatomy Lab.Montreal Neurological InstituteMontrealCanada

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