Suppression of Active Neuronal Death by Immune Interferon
The survival of neuronal cells depends on the presence of trophic factors. To date, nerve growth factor (NGF) is the only trophic factor which is chemically well characterized and of proven physiological significance (1). NGF is necessary for the survival and function of sympathetic and neural crest-derived sensory neurons. It is becoming clear that NGF is also important for the basal forebrain cholinergic neurons in CNS (2), a cell group involved in memory and which degenerates in Alzheimer’s disease.
KeywordsNerve Growth Factor Neuronal Cell Death Trophic Factor Sympathetic Neuron Adenylate Kinase
Unable to display preview. Download preview PDF.
- 1.Thoenen, H., and Barde, Y. A., 1980, Physiology of nerve growth factor, Physiol. Rev., 60: 1284.Google Scholar
- 4.Oppenheim, R. W., and Prevette, D. M., 1988, Reduction of naturally occurring neuronal death in vivo by the inhibition of protein and RNA synthesis, Soc. Neurosci. Abstr., 14: 368.Google Scholar
- 7.Saarma, M., Toots, U., Raukas, E., Zhelkovsky, A., Pivazian, A., and Neuman, T., 1986, Nerve growth factor induces changes in (2’-5’)oligo(A) synthetase and 2’phosphodiesterase activities during differentiation of PC12 pheochromocytoma cells, Exp. Cell. Res., 166: 229.Google Scholar
- 8.Cohen, J. J., and Duke, R. C., 1984, Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death, J. Immunol., 132: 38.Google Scholar
- 9.Duke, R. C., and Cohen, J. J., 1986, IL-2 addiction: Withdrawal of growth factor activates a suicide program in dependent T cells, Lymphokine Res., 5: 289.Google Scholar
- 10.Stanisic, T., Sodlowski, R., Lee, C. and Grayhack, J. T., 1978, Partial inhibition of castration-induced ventral prostate regression with actinomycin D and cycloheximide, Invest. Urol., 16: 15.Google Scholar
- 13.Buttyan, R., Zakeri, Z, Lockshin, R., and Wolgemuth, D., 1988, Cascade induction of c-fos, c-myc, and heat shock 70K transcripts during regression of the rat ventral prostate gland, Mol. Endocrinol., 2: 650.Google Scholar
- 14.Arenzana-Seisdedos, F., Virelizier, J. L., and Fiers, W., 1985, Interferons as macrophage-activating factors. III. Preferential effects of interferon-gamma on the interleukin-1 secretory potential of fresh or aged human monocytes, J. Immunol., 134: 2444.Google Scholar
- 15.Gerrard, T. L., Siegel, J. P., Dyer, D. R., and Zoon, K. C., 1987, Differential effects of interferon-a and interferon-gamma on interleukin-1 secretion by monocytes, J. Immunol., 138: 2535.Google Scholar