Suppression of Active Neuronal Death by Immune Interferon

  • Eugene M. JohnsonJr.
  • David P. Martin
  • Beth K. Levy
  • Jason Y. Chang
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)


The survival of neuronal cells depends on the presence of trophic factors. To date, nerve growth factor (NGF) is the only trophic factor which is chemically well characterized and of proven physiological significance (1). NGF is necessary for the survival and function of sympathetic and neural crest-derived sensory neurons. It is becoming clear that NGF is also important for the basal forebrain cholinergic neurons in CNS (2), a cell group involved in memory and which degenerates in Alzheimer’s disease.


Nerve Growth Factor Neuronal Cell Death Trophic Factor Sympathetic Neuron Adenylate Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Eugene M. JohnsonJr.
    • 1
  • David P. Martin
    • 1
  • Beth K. Levy
    • 1
  • Jason Y. Chang
    • 1
  1. 1.Department of PharmacologyWashington University Medical SchoolSt. LouisUSA

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