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A Functionalized Congener Approach to Muscarinic Ligands

  • Kenneth A. Jacobson
  • Barton J. Bradbury
  • Jesse Baumgold
Part of the Advances in Behavioral Biology book series (ABBI, volume 36)

Abstract

Most clinically available cholinergic drugs (eg. the agonist pilocarpine, 1, and the antagonist atropine, 2, Figure 1) are non-selective in their interaction with muscarinic receptor subtypes. The recent cloning, sequencing, and expression of five separate genes for muscarinic receptors (1–4), has raised the possibility of developing novel organic compounds that act as agonists or antagonists at one of these subtypes. Selective compounds could be therapeutically useful in treating a variety of diseases, including Alzheimer’s disease, cardiac disease, neurogenic bladder, and certain sleep disorders. Futhermore, such specific compounds, by virtue of their subtype selectivity, should be devoid of many of the side effects of currently used compounds.

Keywords

Muscarinic Receptor Adenosine Receptor Muscarinic Agonist Muscarinic Receptor Subtype Pyrrolidone Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Kenneth A. Jacobson
    • 1
  • Barton J. Bradbury
    • 1
  • Jesse Baumgold
    • 2
  1. 1.Laboratory of ChemistryNIDDKBethesdaUSA
  2. 2.Laboratory of Molecular and Cellular Neurobiology, Section on Membrane BiochemistryNINDS, NIHBethesdaUSA

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