Skip to main content
SpringerLink
Log in

Treatment of Uraemic Anaemia with Recombinant Human Erythropoietin

  • Conference paper
New Perspectives in Hemodialysis, Peritoneal Dialysis, Arteriovenous Hemofiltration, and Plasmapheresis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 260))

Abstract

Several factors have been involved in the pathogenesis of uraemic anaemia: inhibition of erythropoiesis and hyperhaemolysis to uraemic toxins (1); iron deficiency due to blood losses in the extracorporeal circuit (2); severe hyperparathyroidism with osteitis fibrosa (3) ; abnormally high concentrations of aluminium (4). However, there is general agreement that the main cause of uraemic anaemia is the insufficient production of erythropoietin from the diseased kidneys (5).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Markson, J.L., Renniec, J.B.: The anaemia of chronic renal insufficiency. Scott. Med. J. 1:320 (1970)

    Google Scholar 

  2. Loge, J.P., Lange, R.D., Moore, C.V.: Characterization of the anemia associated with chronic renal insufficiency. Am. J. Med. 24:4 (1958).

    Article  PubMed  CAS  Google Scholar 

  3. Weinberg, S.G., Lubin, A., Wiener, S., Deoras, M.P., Ghose, M.K., Kogelmann, R.C.: Myelofibrosis and renal osteodystrophy. Am. J. Med. 63: 755 (1977).

    Article  PubMed  CAS  Google Scholar 

  4. Kaiser, L., Schwartz, K.A.: Aluminium induced anaemia. Am. J. Kidney Dis. 6:348 (1985) .

    PubMed  CAS  Google Scholar 

  5. Eschbach, J.W., Adamson, J.W.: Anaemia of end stage renal disease. Kidney Int. 28:1 (1985).

    Article  PubMed  CAS  Google Scholar 

  6. Eschbach, J.W., Egrie, J.C., Downing, M.R., Browne, J.K., Adamson, J.W.: Correction of anaemia of end stage renal disease with recombinant human erythropoietin. N. Enal. J. Med. 316:73 (1987).

    Article  CAS  Google Scholar 

  7. Winearls, C.G., Oliver, D.O., Pippard, M.J., Reid, C., Downing, M.R., Cotes, P.M.: Effect of human erythropoietin derived from recombinant DNA on the anaemia of patients maintained by chronic haemodialysis. Lancet 2:1175 (1986).

    Article  PubMed  CAS  Google Scholar 

  8. Casati, S., Passerini, P., Campise, M., Graziani, G., Cesana, B., Perisic, M. , Ponticelli, C.: Benefits and risks of protracted treatment with human recombinant erythropoietin in patients having haemodialysis. Brit. Med. J. 4:1017 (1987) .

    Article  Google Scholar 

  9. Sundal, E., Bariety, J., Blumberg, A., Bommer, J., Canaud, B., Danielson, B., Kreis, H., Lamperi, S., Michielsen, P., Rhyner, K. , Ponticelli, C., Schaefer, R.M. , Verbeelen, D. , Zehnder, C., Kaeser, U. : Correction of the anaemia of chronic renal failure with recombinant human erythropoietin: results from a multicentre study in 150 haemotransfusion dependent patients (submitted for publication).

    Google Scholar 

  10. Eschbach, J.W., Adamson, J.W.: Correction of the anemia of hemodialysis patients with recombinant human erythropoietin. Results of a multicentre study. Kidney Int. 33:189 (1988).

    Google Scholar 

  11. Bommer, J., Kugel, M., Schoeppe, W., Brunkhorst, R., Samtleben, W., Bramsiepe, W., Scigalla, P.: Dose related effects of recombinant human erythropoietin on erythropoiesis. Results of a multicentre trial in patients with end-stage renal disease. Contr. Nephrol. Vol. 66, p 85, Karger, Basel, (1988).

    CAS  Google Scholar 

  12. Akizawa, T., Koshikawa, S., Takaku, F., Urabe, A., Akiyama, N., Mimura, N., Otsubo, O., Nihei, H., Suzuki, Y., Kawaguchi, Y., Ota, K., Kubo, K., Marumo, F., Maeda, T.: Clinical effect of recombinant human erythropoietin on anemia associated with chronic renal failure. A multi institutional study in Japan. Int. J. Artif. Organs. 11; 343 (1988).

    PubMed  CAS  Google Scholar 

  13. Eschbach, J.W., Adamson, J.W.: Recombinant human erythropoietin: Implications for nephrology. Am. J. Kidney Dis. 11:203 (1988).

    PubMed  CAS  Google Scholar 

  14. Hampl, H., Riedel, E., Wendel, G., Stabeil U., Kessel, M.: Influence of parathyroid hormone on exogenous erythropoietin stimulated erythropoiesis in hemodialysis patients. Kidney Int. 33:224 (1988).

    Google Scholar 

  15. Winearls, C.G.: Use of erythropoietin in patients with end-stage renal disease. Royal Soc. Med. 1:2 (1988).

    Google Scholar 

  16. Bommer, J., Alexiou, C., Müller-Bühl, U. , Eifert, J., Ritz, E.: Recombinant human erythropoietin therapy in hemodialysis patients. Dose determination and clinical experience. Nephrol. Dial. Transpl. 2:23 (1987).

    Google Scholar 

  17. Mayer, G., Thum, J. Cada, E.M., Stummvoll, H.K., Graf, H.: Working capacity is increased following recombinant human erythropoietin treatment. Kidney Int. 34:525 (1988).

    Article  PubMed  CAS  Google Scholar 

  18. Grützmacher, P., Bergmann M., Löw, I., Schoeppe, W.: Cardiac changes in haemodialysis patients treated by recombinant human erythropoietin. Int. Soc. Blood Purification, Vicenza June, Abstr. 36 (1988).

    Google Scholar 

  19. London, G.M. , Zins, B. , Naret, C., Pannier, B., Berthelot, J.M., Peteriongo, F., Drueke, T., Jacquot, C.: Hemodynamic changes in haemodialysis patients in response to recombinant erythropoietin. EDTA-ERA Madrid, Abstr. 211 (1988).

    Google Scholar 

  20. Kühn, K., Talartschik, H., Koch, K.M., Eisenhauer, T., Nonnast-Daniel, B., Scheler, F., Brunkhorst, R., Reimers, E.: Plasma atrial natriuretic peptide levels after partial correction of renal anemia by recombinant human erythropoietin. EDTA-ERA Madrid, Abstr. 210 (1988).

    Google Scholar 

  21. Mangiarotti, R., Pierini, A., Casati, S., Passerini, P., Ambroso, G.C., Pini, C., Graziani, G. : Modificazioni delia funzionalità cardiaca nell’emodializzato in trattamento con eritropoietina. Nefroloqia, Acta Medica, Roma 419 (1987).

    Google Scholar 

  22. Paganini, E., Thomas, T., Fouad, F., Garcia, J., Bravo, E.: The correction of anemia in hemodialysis patients using recombinant human erythropoietin: hemodynamic effects. Kidney Int. 33:204 (1988).

    Google Scholar 

  23. Deykin, D.: Uremic bleeding. Kidney Int. 24:698 (1983).

    Article  PubMed  CAS  Google Scholar 

  24. Livio, M., Marchesi, D., Remuzzi, G., Gotti, E., Mecca, G., DeGaetano, G.: Uraemic bleeding: role of anemia and beneficial effect of red-cell transfusions. Lancet 2:1013 (1982).

    Article  PubMed  CAS  Google Scholar 

  25. Moia, M., Vizzotto, L., Cattaneo, M., Mannucci, P.M., Casati, S., Ponticelli, C.: Improvement in the haemostatic defect of uraemia after treatment with recombinant human erythropoietin. Lancet 2:1227 (1987).

    Article  PubMed  CAS  Google Scholar 

  26. Ishibashi, T., Koziol, J.A., Burstein, S.A.: Human recombinant erythropoietin promotes differentiation of murine megakaryocytes in vitro. J. Clin. Invest. 79: 286 (1987).

    Article  PubMed  CAS  Google Scholar 

  27. Grützmacher, P., Bergmann, M., Nattermann, U., Weinreich, T., Reimers, E., Pollak, M.: Beneficial and adverse effects of correction of anaemia by recombinant human erythropoietin in patients on maintenance haemodialysis. Contr. Nephrol. Vol. 66, p 104, Karger, Basel, (1988).

    Google Scholar 

  28. Jacquot, C., Ferragu-Haguet, M. , Lefebvre, A., Berthelot, J.M., Peteriongo, F., Castaigne, J.P.: Recombinant human erythropoietin and blood pressure. Lancet 2:1083 (1987).

    Article  PubMed  CAS  Google Scholar 

  29. Tomson, C.R.V., Venning, M.C., Ward, M.K.: Blood pressure and erythropoietin. Lancet 1:351 (1988).

    Article  Google Scholar 

  30. Edmunds, M.S., Walls, J.: Blood pressure and erythropoietin. Lancet 1:352 (1988).

    Google Scholar 

  31. Neff, M.S., Kim, K.E., Persoff, M., Onesti, G., Swartz, C.: Haemodynamics of uraemic anaemia. Circulation 43:876 (1971).

    PubMed  CAS  Google Scholar 

  32. Capelli, J.P., Kasparian, H.: Cardiac work demands and left ventricular function in end-stage renal disease. Ann. Intern. Med. 86:261 (1977).

    PubMed  CAS  Google Scholar 

  33. Colemann, T.G.: Hemodynamics of uremic anemia. Circulation 45:510 (1972).

    Google Scholar 

  34. Martin, J., Moncada, S.: Blood pressure, erythropoietin and nitric oxide. Lancet 1:644 (1988).

    Article  PubMed  CAS  Google Scholar 

  35. Schaefer, R.M., Kuerner, B., Zech, M., Denninger, G., Borneff, C., Heidland, A.: Treatment of the anemia of hemodialysis patients with recombinant human erythropoietin. Int. J. Artif. Organs 11:249 (1988).

    PubMed  CAS  Google Scholar 

  36. Stivelmann, J., van Wick, D., Kirlin, D., Ogden, D.: Use of recombinant erythropoietin with high flux dialysis does not worsen azotemia or shorten access survival. Kidney Int. 33:239 (1988).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Divisione di Nefrologia, IRCCS Ospedale Maggiore, Milan, Italy

    Claudio Ponticelli, Stefano Casati & Mariarosaria Campise

Authors
  1. Claudio Ponticelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefano Casati
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mariarosaria Campise
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Universitätsklinik, Freiburg, Federal Republic of Germany

    W. H. Hörl  & P. J. Schollmeyer  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Plenum Press, New York

About this paper

Cite this paper

Ponticelli, C., Casati, S., Campise, M. (1989). Treatment of Uraemic Anaemia with Recombinant Human Erythropoietin. In: Hörl, W.H., Schollmeyer, P.J. (eds) New Perspectives in Hemodialysis, Peritoneal Dialysis, Arteriovenous Hemofiltration, and Plasmapheresis. Advances in Experimental Medicine and Biology, vol 260. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5718-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5718-6_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5720-9

  • Online ISBN: 978-1-4684-5718-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation