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Mechanisms and Consequences of Complement Activation During Hemodialysis

  • Michel D. Kazatchkine
  • Nicole Haeffner-Cavaillon
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 260)

Abstract

Activation of the complement system and secondary leukocyte activation mediate, both directly and indirectly, the acute and chronic effects resulting from immunological bioincompatibility of extracorporeal circuits. This manuscript briefly reviews the mechanisms and consequences of complement activation during hemodialysis. It focuses on recent studies from our laboratory suggesting a role for specific antibodies in the initiation of alternative pathway activation by cellulosic membranes, and indicating that circulating monocytes are stimulated to produce Interleukin-1 (IL-1) in vivo during bioincompatible hemodialysis.

Keywords

Complement Activation Cellulosic Membrane Extracorporeal Circuit Polysulfone Membrane Alternative Pathway Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Michel D. Kazatchkine
    • 1
  • Nicole Haeffner-Cavaillon
    • 1
  1. 1.Unité d’Immunopathologie, Inserm U28Hopital BroussaisParisFrance

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