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Drug Therapy During Continuous Arteriovenous Hemofiltration

  • Erich Keller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 260)

Abstract

Since the first description of continuous arteriovenous hemofiltration as a method of emergency fluid removal (Kramer et al. 1977), this measure has gained wide acceptance predominantly as a supportive treatment of acute renal failure in critically ill patients. It has been shown that the machinefree hemofiltration allows liberal parenteral nutrition without the risk of fluid overload. In addition it has some capacity to remove uremic toxins. The method can be applied without sophisticated apparative equipment and without trained dialysis personal being familiar with the problems of extracorporal circulation.

Keywords

Acute Renal Failure Drug Clearance Total Clearance Drug Elimination Ultrafiltration Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bennett W.M., Aronoff G.R., Morrison G., Golper T.A., Pulliam J., Wolfson M., Singer I., 1983, Drug prescribing in renal failure: Dosing guidelines for adults, Am. J. Kidney. Dis., 3: 155.PubMedGoogle Scholar
  2. Bodenham A., Shelly M.P., Park G.R., 1988, The altered pharmacokinetics and pharmacodynamics of drugs commonly used in critically ill patients, Clin. Pharmacokin., 14: 347.CrossRefGoogle Scholar
  3. Bozkurt F., Hörl W.H., 1987, Bedeutung der kontinuierlichen arteriovenösen Hämofiltration (CAVH) und arteriovenösen Hämodiafiltration (AV-HDF) in der Intensivtherapie, Intensivmed., 24: 248.Google Scholar
  4. Drusano G.L., Standiford H.C., 1985, Pharmacokinetic profile of Imipenem/Cilastatin in normal volunteers, Am. J. Med., 78: 47.PubMedCrossRefGoogle Scholar
  5. Gibson T.P., Demetriades J.L., Bland J.A., 1985, Imipenem/Cilastatin: Pharmacokinetic profile in renal insufficiency, Am. J. Med., 78 (suppl. 6 a): 54.PubMedCrossRefGoogle Scholar
  6. Golper T.A., Pulliam J., Bennett W.M., 1985, Removal of therapeutic drugs by continuous arteriovenous hemofiltration, Arch. Int. Med., 145: 1651.CrossRefGoogle Scholar
  7. Golper T.A., Saad A.M.A., Morris CD., 1986, Gentamycin and Phenytoin sieving through hollow fiber polysulfone hemofilters, Kidney Int., 30: 937.PubMedCrossRefGoogle Scholar
  8. Hilt H., Keller F., 1987, Elimination von Pharmaka durch Hämofiltration, Anästh. Intensivther. Notfallmed., 22: 278. Kates R.E., Leier C.V., 1987, Dobutamine pharmacokinetics in severe heart failure, Clin. Pharmacol. Ther., 24: 537.PubMedCrossRefGoogle Scholar
  9. Kates R.E., Leier C.V., 1987, Dobutamine pharmacokinetics in severe heart failure, Clin. Pharmacol. Ther., 24: 537.Google Scholar
  10. Keller E., Fecht H., Böhler J., Schollmeyer P., 1989, Single dose kinetics of Imipenem Cilastatin during continuous arteriovenous hemofiltration in intensive care patients, Nephr. Dial. and Transplant., (submitted).Google Scholar
  11. Kramer P., Wigger W., Rieger J., Mattheai D., Scheler F., 1977, Arteriovenous hemofiltration : a new and simple method for treatment of overhydrated patients resistant to diuretics, Klin. Wochenschr., 55: 1121.PubMedCrossRefGoogle Scholar
  12. Lau A.H., Kronfol N.O., John E., 1987, Increased vancomycin elimination with continuous hemofiltration, Trans. Am. Soc. Artif. Intern. Organs., 33: 772.Google Scholar
  13. Norrby S.R., Rogers J.D., Ferber F., Jones K.H., Zachei A.G., Weidner L.L., Demetriades J.L., Gravellese D.A., Hsieh Y.K., 1984, Disposition of radiolabeled Imipenem and Cilastatin in normal human volunteers, Antimicrob. Agents. Chemother., 26: 707.PubMedGoogle Scholar
  14. Reeves D.S., Chapman S.T., Davies A.J., Ferber V.F., Rogers J.D., 1983, Human pharmacokinetics of N-Formimidoyl thienamycin alone and in combination with a dehydropeptidase inhibitor (MK 791 ) and probenecid. In: Spitzy KH, Karrer K eds., Proceedings of the thirteens International congress of Chemotherapy. Vienna, Austria, Vol 3, part 95: 30.Google Scholar
  15. Stevens P.E., Riley B., Davies S.P., Gower P.E., Brown E.A., Kox W., 1988, Continuous arteriovenous hemodialysis in critically ill patients, Lancet 2: 150.PubMedCrossRefGoogle Scholar
  16. Vanholder R., Landschoot N.V., De Smed R., Schoots A., Ringoir S., 1988, Drug protein binding in chronic renal failure: Evaluation of nine drugs, Kidney Int., 33: 996.PubMedCrossRefGoogle Scholar
  17. Zarowitz B.J., Anandan J.V., Dumler F., Jayashankar J., Levin N., 1986, Continuous arteriovenous hemofiltration of aminoglycoside antibiotics in critically ill patients. J. Clin. Pharmacol., 26: 686.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Erich Keller
    • 1
  1. 1.Department of Medicine, Division of NephrologyUniversity of FreiburgGermany

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