Pharmacokinetic Aspects of Drug Transport in Continuous Ambulatory Peritoneal Dialysis

  • Norbert Lameire
  • Severin Ringoir
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 260)


Pharmacokinetics involve the study of the time-course of the concentration of a drug or, in some cases, its metabolites, in different parts of the organism. Mathematical models are used to describe this time-course. These models allow prediction of the concentrations as a function of dosage, route of administration and of factors such as disease states. This time-course of the plasma concentrations can usually be adequately described by a model in which the body is viewed as one compartment, in which the drug is distributed rapidly and homogeneously. In a two-compartment model, the body is divided in a central compartment which contains the plasma, but also the extra-cellular fluid of highly perfused organs such as heart, lung, liver and kidney, and a peripheral compartment in which the drug is distributed at the slower rate. Fig. 1 describes the plasma concentration of a drug as a function of time for a one-compartmental and a two-compartmental model, respectively.


Peritoneal Dialysis Continuous Ambulatory Peritoneal Dialysis Total Body Clearance Peak Plasma Level Drug Protein Binding 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Norbert Lameire
    • 1
  • Severin Ringoir
    • 1
  1. 1.Renal DivisionUniversity HospitalGhentBelgium

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