Protein Catabolic Factors in Patients on Renal Replacement Therapy

  • Jonas Bergström
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 260)


Several reports have documented that malnutrition is frequently present in patients with maintenance haemodialysis therapy1–5. Signs of malnutrition in regular dialysis patients are reduced muscle mass assessed by anthropometric methods, low concentration of albumin, transferrin, and other liver-derived proteins, low alkali-soluble protein in muscle in relation to dry fat-free weight and DNA, abnormal plasma amino acid and intracellular amino acid profiles, similar to those found in untreated uremia, indicating that dialysis does not reverse these abnormalities. It is generally accepted that suboptimal nutritional status is associated with increased morbidity and may contribute to poor rehabilitation and quality of life. Cutaneous energy and other immune alterations strikingly similar to those observed in malnutrition have been documented in haemodialysis patients3,6,7 suggesting that protein-energy malnutrition may be a risk factor for infection and septicemia. Malnutrition is an important factor for morbidity and mortality in haemodialysis patients8 , 9.


Peritoneal Dialysis Continuous Ambulatory Peritoneal Dialysis Protein Catabolism Uremic Patient Dialysis Fluid 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Jonas Bergström
    • 1
  1. 1.Department of Renal MedicineHuddinge University Hospital, Karolinska InstituteHuddingeSweden

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