Strategies for the Development of a Rotavirus Vaccine Against Infantile Diarrhea with an Update on Clinical Trials of Rotavirus Vaccines

  • Albert Z. Kapikian
  • Jorge Flores
  • Karen Midthun
  • Yasutaka Hoshino
  • Kim Y. Green
  • Mario Gorziglia
  • Kazuo Nishikawa
  • Robert M. Chanock
  • Louis Potash
  • Irene Perez-Schael
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)


It is an honor and privilege to participate in this Symposium on “The Immune Response to Viral Infections” in this historic, celebrated city of countless renowned splendors where artistic and intellectual giants such as Leonardo da Vinci, Michelangelo, Dante, Machiavelli, Giotto, Botticelli, Galileo, Cellini, The Medici and the navigator Amerigo Vespucci exerted such profound influence, for it was here that Florentine scholars, painters, architects and craftsmen began the Renaissance. Although this pinnacle of human expression was unleashed with such intensity beginning some 500 years ago, thus laying the foundation for striking artistic, cultural and intellectual achievements, it is ironic that this energy did not successfully pollinate concurrently the domain of medicine since progress in discovering the etiologic agents of various scourges of humankind and elucidation of means to eliminate them were not forthcoming for centuries. Indeed, the mortality rate in the 15th century was quite high as documented in the Florentine dowry records of under one year to 19 year old females, with the highest rate occurring, by far, in the less than 5 year-old age group (Morrison et al., 1977).


Norwalk Virus Infantile Diarrhea Nonbacterial Gastroenteritis Rhesus Monkey Lung Jennerian Approach 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Albert Z. Kapikian
    • 1
  • Jorge Flores
    • 1
  • Karen Midthun
    • 1
  • Yasutaka Hoshino
    • 1
  • Kim Y. Green
    • 1
  • Mario Gorziglia
    • 1
  • Kazuo Nishikawa
    • 1
  • Robert M. Chanock
    • 1
  • Louis Potash
    • 2
  • Irene Perez-Schael
    • 3
  1. 1.Laboratory of Infectious Diseases, National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaUSA
  2. 2.Flow Laboratories, Inc.McLeanUSA
  3. 3.Central University of VenezuelaCaracasVenezuela

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