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Physiological Mechanisms of Production and Action of Interferons in Response to Viral Infections

  • F. Dianzani
  • G. Antonelli
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)

Abstract

The Interferons (IFNs) are the members of a family of proteins produced by animal cells in response to a variety of stimuli. Although originally described as an extraordinarily potent antiviral agents, they were subsequently found to affect many other cellular functions and now they are considered pleiotropic hormonal effectors. There are several experimental and clinical evidences that IFNs represent an active defense against viruses in vivo : i. in many viral infections a strong correlation has been established between IFN production and natural recovery; ii. inhibition of IFN production or action enhances the severity of infection; iii. treatment with IFN -usually protects animals from several viral infections.

Keywords

Current Review Antiviral State Amnion Cell Hepatitis NANB Interferon System 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • F. Dianzani
    • 1
  • G. Antonelli
    • 1
  1. 1.Institute of VirologyUniversity “La Sapienza”RomeItaly

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