Possible Factors Contributing to Persistence of Cytomegalovirus Infection
The purpose of this article is to discuss factors which may contribute to the persistance of cytomegalovirus (CMV) infection in the face of host responses. In general, available evidence suggests that cell-mediated rather than humoral immunity is important for the control of CMV infection. For example, immunosuppressed humans die of progressive HCMV infection in the presence of normal or high antibody levels (Rasmussen et al., 1982). Furthermore T cell deficient mice are more susceptible to MCMV infection than normal controls (Grundy and Melief, 1982) and transferred T cells confer protection (Grundy and Melief, 1982; Starr and Allison, 1977; Ho, 1980; Reddehase et al., 1985). Therefore I intend to focus on factors which may influence the expression and effectiveness of cell-mediated mechanisms against CMV infection.
KeywordsNatural Killer Cell Gamma Interferon Recombinant Vaccinia Virus MCMV Infection Cell Deficient Mouse
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