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Characterization of Anti Liver Kidney Microsomal Antibody Associated with Chronic HDV Infection by Immunoblotting

  • M. Lenzi
  • M. Fusconi
  • L. Selleri
  • A. Caselli
  • F. Cassani
  • A. Craxi
  • F. B. Bianchi
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)

Abstract

Cytoplasmic antibodies directed against antigen(s) present in the membranes of the endoplasmic reticulum have been reported in a proportion of patients with chronic HBV-HDV infection (Crivelli et al.,1981). While the immunofluorescence (IFL) pattern associated with LKMδ antibody is quite similar to that of the liver kidney microsomal antibody (LKM) described by Rizzetto et al. (1973) and associated with an autoimmune type of chronic active hepatitis (Thomas, 1980), the target antigen(s) was supposed to be different on the basis of blocking experiments. The target antigen of LKM antibody has been recently partially identified as a 50kD protein located in the membranes of the smooth endoplasmic reticulum (Alvarez et al., 1985), while no information is at present available on the nature of LKMδ associated antigen.

Keywords

Primary Biliary Cirrhosis Smooth Endoplasmic Reticulum Antimitochondrial Antibody Autoimmune Type 54kD Molecular Weight 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • M. Lenzi
    • 1
  • M. Fusconi
    • 1
  • L. Selleri
    • 1
  • A. Caselli
    • 1
  • F. Cassani
    • 1
  • A. Craxi
    • 1
    • 2
  • F. B. Bianchi
    • 1
  1. 1.Istituto di Clinica Medica IIUniversity of BolognaItaly
  2. 2.Clinica Medica R and PneumologiaUniversity of PalermoItaly

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