Influenza Virus Infection Reduces Cellular Immunity Functions

  • V. Del Gobbo
  • E. Balestra
  • S. Marini
  • N. Villani
  • R. Caliò
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)


In recent years, detailed information has been accumulated 1,2,3, that cellular, as well as humoral, immune responses play an important role in the clearing of influenza virus and in the recovery phase of infection. On the other hand, influenza virus, such as many viruses, during the acute stages of infection is able to inhibit cellular immune functions as shown by Reiss, and Rodgers5. Little is known about this mechanism of immunosuppression.


Influenza Virus Spleen Cell Infected Mouse Newcastle Disease Virus Influenza Virus Infection 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    Ada G.L., Leung K.N., Ertl H.C.: An analysis of effector T cell generation and function in mice exposed to Influenza A or Sendai viruses. Immunol.Rev., 58, 5, (1981).PubMedCrossRefGoogle Scholar
  2. 2).
    Daisy J.A., Toipin M.D., Quinnan G.V., Rook A.H., Murphy B.R., Mitthal K., Clemenis M.L., Mullinlx M.G., Kiley S.C., Ennis F.A.: Influenza A infection in human volunteers, pag.443 in The replication of negative strand virus, Bishop, D.M.L., Compans, R.W. Ed., Elsevier, North-Holland, (1981).Google Scholar
  3. 3).
    Ennis A.: Some newly recognized aspects of resistence against and recovery from influenza. Archives of Virology, 73, 207, (1982).PubMedCrossRefGoogle Scholar
  4. 4).
    Reiss C,S., Schul man J.L.: Cellular Immune Responses of Mice to Influenza Virus Infection., Cellular Immunology, 56, 502, (1980).PubMedCrossRefGoogle Scholar
  5. 5).
    Rodgers B., Mins CA.: Interaction of Influenza Virus with mouse macrofages. Infect. Immun., 31, 751, (1981).PubMedGoogle Scholar
  6. 6).
    Garaci E. , Caliò R. , Djaczenko W. : Effect of Influenza virus PR8 infection on thymus in Intarrt and adrenolectomized mice. Experentia, 30, 358, (1974).CrossRefGoogle Scholar
  7. 7).
    Gillis S., Ferm M.M. Ou W., Smith KA.: T-cell growth factor: parameters of production and a quantitative microassay for activity. J. Immunol., 120, 2027, (1978).PubMedGoogle Scholar
  8. 8).
    Herberman RB. and Ortaldo J.R.: Natural killer cells: their role in defenses against disease. Science, 24, 214, (1981).Google Scholar
  9. 9).
    Wysocki L.J. and Sato V.L.: “Panning” for lymphocytes: A method for cell selection. Proc. Natl . Acad. Sci. USA, 75, 2844, (1978).PubMedCrossRefGoogle Scholar
  10. 10).
    Hurwitz J.L. and Hackett C.J.: Influenza-specific suppression: contribution of major viral proteins to the generation and function of T suppressor cells. J.Immunology, 135, 2134, (1985).Google Scholar
  11. 11).
    Chouaib S., Chatenoud L., Klatzmann D. and Fradelizi D.: The mechanisms of inhibition of human IL-2 production. J.Immunology, 132, 1851, (1984).Google Scholar
  12. 12).
    Chouaib S. and Fradelizi D.: The mechanism of inhibition of human IL-2 production. J.Immunology, 129, 2463, (1982).Google Scholar
  13. 13).
    Wainberg M.A., Spira B., Boushira M. and Margolese R.G.: Inhibition by human T-lymphotropic virus (HTLV-I) of T-lymphocyte mitogenesis: failure of exogenous T-cell growth factor to restore responsiveness to lectin. Immunology, 54, 1, (1985).PubMedGoogle Scholar
  14. 14).
    Blackett S. and Minis C.A.: Studies of depressed interleukin-2 production by spleen cells from mice following infection with cytomegalovirus. Arch. Virol. 99, 1, (1988)PubMedCrossRefGoogle Scholar
  15. 15).
    Colonna Romano G., Dieli F., Abrignani S., Salerno A. and Colizzi V.: Inhibition of lymphocyte mitogenesis in mice infected with Newcastle disease virus: viral interference with the interleukin system. Immunology, 57, 373, (1986).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • V. Del Gobbo
    • 1
  • E. Balestra
    • 1
  • S. Marini
    • 1
  • N. Villani
    • 1
  • R. Caliò
    • 1
  1. 1.Department of Experimental MedicineII University of RomeItaly

Personalised recommendations