CD4 as the Receptor for Retroviruses of the HTLV Family: Immunopathogenetic Implications
CD4 is the HIV (Human immunodeficiency virus type I) receptor, and the virus seems to bind to it through the Leu3a/0KT4a epitope (Klatzmann et al., 1985), HIV infection may lead to the destruction of CD4+ cells both by direct and indirect mechanisms. Direct mechanisms include the formation of syncitia among infected cells (Lifson et al., 1936). Indirect mechanisms may involve autoimmune reactions, of both cell mediated and humoral types (Klatzmann and Montagnier, 1986).
KeywordsHuman Immunodeficiency Virus Type Antilymphocyte Antibody Normal Human Peripheral Blood Normal Human Peripheral Blood Lymphocyte
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- Gorman SD, Tourvieille B, Pannes JR. Structure of the mouse gene encoding CD4 and unusual transcript in brain. Proc. Natl. Acad. Sci. USA 84, 7644, 1987. Ho DD, Pomeranz JR, Kaplan JC. Pathogenesis of infection with human immunodeficiency virus. N.Eng. J. Med. 317, 278, 1987. Klatzmann DE, Champagne E, Chouret S, Grunest J, Guetart D, Hercend T, Gluckman JC, Montagnier L. T lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature 312, 767, 1985.PubMedCrossRefGoogle Scholar
- Ragona G, Sirianni MC, Soddu S, Vercelli B, Sebastiani G, Picchi M, Aiuti F. Clin, exp. Immunol. 66, 17, 1986.Google Scholar
- Salahuddin SZ, Ablashi DV, Hunter EA, Gonda MA, Sturzenegger S, Markham PD, Gallo RC. HTLV-III infection of EBM genome positive B lymphoid cells with or without detectable T4 antigens. Int. J. Cancer 39, 1987.Google Scholar