Delta Virus Hepatitis

  • Mario Rizzetto
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)


The Hepatitis Delta Virus (HVD) occupies a unique niche in humai virology. At variance with conventional animal viruses, it cannot replicate autonomously but requires the presence of the Hepatitis B Virus (HBV) to initiate infection. It behaves like a defective interfering agent, in that it ihibits the synthesis of the competent HBV helper once its infection is established. This cooperation is reflected in the HD virion, a 36 nm spherical particle formed by an envelope of HBV-derived surface antigen (HBsAg), which encloses the genome and a specific delta antigen (HD-Ag) (1).


Fulminant Hepatitis Hepatitis Delta Virus Helper Virus Woodchuck Hepatitis Virus Defective Virus 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Mario Rizzetto
    • 1
  1. 1.Divisione di GastroenterologiaMolinetteTorinoItaly

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