Persistence of Human Papillomaviruses

  • Judit Acs
  • William C. Reeves
  • William E. Rawls
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)


The role of viruses in the induction of papillomas which may persist and give rise to malignant lesions was demonstrated in animals a number of years ago (Rous and Beard, 1935). More recent observations suggest that a similar relationship could exist in humans infected with certain types of papillomaviruses (HPV) (Gissmann, 1984). The nature of the host-virus interactions leading to persistence of papillomavirus infections are poorly understood as are the factors leading to the development of virus-associated malignant disease. In addition to in-tracellular events controlling virus replication, lesion formation appears to be controlled, in part, by host immune responses. It is our intent in this paper to portray the nature of persistence of human papillomaviruses and to review the role of immune factors in controlling the diseases induced by these viruses.


Cervical Intraepithelial Neoplasia Genital Wart Upstream Regulatory Region Condyloma Acuminata Reserve Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Judit Acs
    • 1
  • William C. Reeves
    • 2
  • William E. Rawls
    • 1
  1. 1.Molecular Virology and Immunology Program Department of PathologyMcMaster UniversityHamiltonCanada
  2. 2.Division of EpidemiologyGorgas Memorial LaboratoriesRepublic of Panama

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