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The Immunobiology of Respiratory Syncytial Virus: Prospects for a Vaccine

  • Erling Norrby
  • Britt Åkerlind
  • Maurice A. Mufson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)

Abstract

Human Respiratory Syncytial Virus (RSV) is a member of the pneumo-virus genus of the family Paramyxoviridae. This virus is the most common cause of severe lower respiratory infections among infants and children, especially children between 2 and 6 months of age (Belshe et al., 1984). All attempts that hitherto have been made to develop a safe and effective RSV vaccine have met with failure. During recent years there has been a rapid accumulation of knowledge about the basic biochemistry and biology of the virus. New possibilities for developing an effective vaccine have become available.

Keywords

Respiratory Syncytial Virus Respiratory Syncytial Virus Infection Human Respiratory Syncytial Virus Respiratory Syncytial Virus Disease Severe Lower Respiratory Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Anderson, L. J., Hierholzer, J. C., Tsou, C., Hendry, R. M., Fernie, B. F., Stone, Y., and Mc Intosh, K, 1985, Antigenic characterization of respiratory syncytial virus strains with monoclonal antibodies, J. Inf. Dis., 151:626.CrossRefGoogle Scholar
  2. Belshe, R. B., Van Voris, L. P., and Mufson, M. A., 1982, Parental administration of live respiratory syncytial virus vaccine: results of a field trial, J. Inf. Dis., 145:311.CrossRefGoogle Scholar
  3. Belshe, R. B., Bernstein, J. M., and Pansby, K. N., 1984, Respiratory syncytial virus, in: “Textbook of Human Virology”, R. B. Belshe, ed., PSG Publishing Co., Littleton.Google Scholar
  4. Buynak, E. B., Weibel, R. E., McClean, A. A., and Hilleman, M. R., 1978, Live respiratory syncytial virus vaccine administered parenterally, Proc. Soc. Exptl. Biol. Med., 157:636.Google Scholar
  5. Buynak, E. B., Weibel, R. E., Carlson, A. J., McClean, A. A., and Hilleman, M. R., 1979, Further investigations of live respiratory syncytial virus vaccine administered parenterally, Proc. Soc. Exptl. Biol. Med., 160:272.Google Scholar
  6. Chanock, R. M., Kapikian, A. Z., Mills, J., Kim, H. W. , and Parrott, R. H., 1970, Influence of immunologic factors in respiratory syncytial virus disease, Arch. Environ. Health, 21:347.PubMedGoogle Scholar
  7. Chanock, R. M., and Murphy, B. R., 1980, Use of temperature-sensitive and cold-adapted mutant viruses in immunoprophylaxis of acute respiratory tract disease, Rev. Inf. Dis., 2:421.CrossRefGoogle Scholar
  8. Coates, H. V, Kendrick, L., and Chanock, R.M., 1963, Antigenic differences between two strains of RS virus, Proc. Soc. Exptl. Biol. Med., 112:958.Google Scholar
  9. Doggett, J. E., and Taylor-Robinson, D. T., 1965, Serological studies with respiratory syncytial virus, Arch. Ges. Virusforsch., 15:601.PubMedCrossRefGoogle Scholar
  10. Fernie, B. F., and Gerin, J. L., 1982, Immunochemical identification of viral and nonviral proteins of the respiratory syncytial virus virion, Inf. Immun., 37:243.Google Scholar
  11. Fulginiti, V. A., Eller, J. J., Sieber, O. F., Joyner, J. W., Minamitani, M., and Meiklejohn, G., 1967, Respiratory virus immunization. I. A field trial of two inactivated respiratory virus vaccines: an aqueous trivaient para influenza virus vaccine and an alum-precipitated respiratory syncytial virus infection, Acta Med. Scand., 182:323Google Scholar
  12. Gimenez, H. B., Hardman, N., Keir, H. M. , and Cash, P., 1986, Antigenic variation between human respiratory syncytial virus isolates, J. Gen. Virol., 67:863.PubMedCrossRefGoogle Scholar
  13. Gruber, C., and Levine, S., 1983, Respiratory syncytial virus polypeptides. III. The envelope associated proteins, J. Gen. Virol., ” 64:825.PubMedCrossRefGoogle Scholar
  14. Gruber, C., and Levine, S., 1985, Respiratory syncytial virus polypeptides. IV. The oligosaccarides of the glycoproteins, J. Gen. Virol., 66:417.PubMedCrossRefGoogle Scholar
  15. Hendry, R. M., Burns, J. C., Walsh, E. E., Graham, B. S., Wright, P. F., Hemming, V. G., Rodriguez, W. J., Kim, H. W., Prince, G. A., Mc In tosh, K., Chanock, R. M., and Murphy, B. R., 1988, Strain specific serum antibody responses in infants undergoing primary infection with respiratory syncytial virus, J. Inf. Dis., 157:640.CrossRefGoogle Scholar
  16. Huang, Y. T., Collins, P. L., and Wertz, G. W., 1985, Characterization of the 10 proteins of human respiratory syncytial virus, identification of a fourth envelope associated protein, Virus Res., 2:157.PubMedCrossRefGoogle Scholar
  17. Johnson Jr., P. R., Olmsted, R. A., Prince, G. A., Murphy, B. R., Ailing, D. W., Walsh, E. E., and Collins, P. L., 1987, Antigenic related-ness between glycoproteins of human respiratory syncytial virus subgroups A and B: Evaluation of the contributions of F and G glycoproteins to immunity, J. Virol., 61:3163.PubMedGoogle Scholar
  18. Kapikian, A. Z., Mitchell, R. H., Chanock, R. M., Shvedoff, R. A., and Stewart, C. E., 1969, An epidemiologic study of altered clinical reactivity to respiratory syncytial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine, Am. J. Epid., 89:405.Google Scholar
  19. Kim, H. W., Canchola, J. G. , Brandt, C. P., Pyles, G., Chanock, R. M., Jensen, K., and Parrott, R. H., 1969, Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine, Am. J. Epid., 89:422.Google Scholar
  20. Mufson, M. A., Örvell, C., Rafnar, B., and Norrby, E., 1985, Two distinct subtypes of human respiratory syncytial virus, J. Gen. Virol., 66:2111PubMedCrossRefGoogle Scholar
  21. Mufson, M. A., Belshe, R. B., Örvell, C., and Norrby, E., 1987, Subgroup characteristics of respiratory syncytial virus strains recovered from children with two consecutive infections, J. Clin. Microbiol., 25:1535.PubMedGoogle Scholar
  22. Olmsted, R. A., Elango, N., Prince, G. A., Murphy, B. R., Johnson, P. H., Moss B., Chanock, R. M., and Collins, P. L., Expression of the F glycoprote in of respiratory syncytial virus by a recombinant vaccinia virus: Comparison of the individual contributions of the F and G glycoproteins to host immunity, Proc. Natl. Acad. Sci. USA, 83:7462.Google Scholar
  23. Prince, G. A., Potash, L., Horswood, R. L., Camargo, E., Suffin, S. C., Johnson, R.A., and Chanock, R. M., 1979, Intramuscular inoculation of live respiratory syncytial virus induces immunity in cotton rats, Inf. Immun., 23:723.Google Scholar
  24. Prince, G. A, Jenson, A. B., Hemming, V. G., Murphy, B. R., Walsh, E. E., Horswood R. L., and Chanock, R. M., 1986, Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin inactivated virus, J. Virol., 57:721.PubMedGoogle Scholar
  25. Satake, M., Coligan, J. E., Elango, N., Norrby, E., and Venkatesan, S., 1985, Respiratory syncytial virus envelope glycoprotein (G) has a novel structure, Nucl. Acid. Res., 13:7795.CrossRefGoogle Scholar
  26. Spriggs, M. K., Olmsted, R. A., Venkatesan, S., Coligan, J. E., and Collins, P. L., 1986, Fusion glycoprotein of human para influenza virus type 3, nucleotide sequence of the gene. Direct identification of the cleavage activation site and comparison with other paramyxoviruses, Virology, 15 2:241.PubMedCrossRefGoogle Scholar
  27. Stott, E. J., Thomas, L. H., Taylor, G., Collins, A. P., Jebbett, J., and Crouch, S., 198 4, A comparison of three vaccines against respiratory syncytial virus in calves, J. Hyg. Camb., 93:251.PubMedCrossRefGoogle Scholar
  28. Stott, E. J., Bell, L. A., Young, K. K., Furze, J., and Wertz, G. W., 1986, Human respiratory syncytial virus glycoprotein G expressed from a recombinant vaccinia virus vector protects mice against live virus challenge, J. Virol., 60:607.PubMedGoogle Scholar
  29. Taylor, G., Stott, E. J., Bew, M., Fernie, B. F., Cote, P. J., Collins, A. P., Hughes, M., and Jebbett, J., 198 4, Monoclonal antibodies protect against respiratory syncytial virus infection in mice, Immunology, 52 :137 .PubMedGoogle Scholar
  30. Thomas, L. H., Stott, E. J., Collins, A. P., Crouch, S., and Jebbett, J., 1984, Infection of gnotobiotic calves with a bovine and human isolate of respiratory syncytial virus. Modification of the response by dexamethasone, Arch. Virol., 79:67.PubMedCrossRefGoogle Scholar
  31. Walsh, E. E., and Hruska, J., 1983, Monoclonal antibodies to respiratory syncytial virus proteins: Identification of the fusion protein, J. Virol., 47:171.PubMedGoogle Scholar
  32. Walsh, E. E., Schlesinger, J. J., and Brandriss, M. W. , 1984a, Purification and characterization of GP90 one of the envelope glycoproteins of respiratory syncytial virus, J. Gen. Virol., 65:761.PubMedCrossRefGoogle Scholar
  33. Walsh, E. E., Schlesinger, J. J., and Brandriss, M. W., 1984b, Protection from respiratory syncytial virus infection in cotton rats by passive transfer of monoclonal antibodies, Inf. Immun., 43:756.Google Scholar
  34. Walsh, E. E., Cote, P. J., Fernie, B. F., Schlesinger, J. J., and Brandriss, M. W., 1986, Analysis of the respiratory syncytial virus fusion protein using monoclonal and polyclonal antibodies, J. Gen. Virol., 67:505.PubMedCrossRefGoogle Scholar
  35. Wertz, G. W., Collins, P. L., Huang, Y., Gruber, C., Levine, S., and Ball, L. A., 1985, Nucleotide sequence of the G protein gene of human respiratory syncytial virus reveals an unusual type of viral membrane protein, Proc. Natl. Acad. Sci. USA, 82:4075.PubMedCrossRefGoogle Scholar
  36. Wright, P. F., Woodend, W. G., and Chanock, R. M., 1970, Temperature-sensitive mutants of respiratory syncytial virus: in vivo studies in hamsters. J. Inf. Dis., 122:501CrossRefGoogle Scholar
  37. Wright, P. F., Belshe, R. B., Kim, H. W., Van-Voris, L. P., and Chanock, R. M., 1982, Administration of highly attenuated live respiratory syncytial virus vaccine to adults and children, Inf. Immun., 37:397.Google Scholar
  38. Wulff, H., Kidd, P., and Wenner, H. A., 1964, Respiratory syncytial virus: Observation on antigenic heterogeneity, Proc. Soc. Exptl. Biol. Med., 115:240.Google Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Erling Norrby
    • 1
  • Britt Åkerlind
    • 1
  • Maurice A. Mufson
    • 2
  1. 1.Department of VirologyKarolinska Institute School of MedicineStockholmSweden
  2. 2.Department of MedicineMarshall University School of Medicine and Veterans Administration Medical CenterHuntingtonUSA

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