Abstract
There can be few of us who have not at some time or another considered a virus to account for a disease of unknown origin. Indeed as long as there are such diseases there will be suggestions that viruses are responsible. But we have to be careful because although the late Peter Medawar quite accurately described a virus as a “piece of bad news wrapped in protein” there is the alternative definition that virus is a Latin word used by doctors meaning “your guess is as good as mine”. However, viruses are unique in that they can do the following things.
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Benditt, E.P., Barrett, T. and McDougall, J.K. (1983) Viruses in the aetiology of atherosclerosis. Proc. Natl. Acad. Sci. 80:6386–6389.
Datta, S.K., McConahey, P.J., Manny, N. et al. (1978) Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand Black mice II The viral envelope glycoprotein gp70. J. Exp. Med. 147:87–881.
Gamble, D.R. (1980) The epidemiology of insulin dependent diabetes, with particular reference to the relationship of virus infection to its aetiology. Epid. Rev. 2:49–70.
Janowitz, H.D. (1981) Crohn’s disease — 50 years later. New Engl. J. Med. 304:1600–1602.
Jenson, A.B., Rosenberg, H.S. and Notkins, A.L. (1980) Pancreatic islet cell damage in children with fatal viral infections. Lancet 2:354–358.
Jenson, A.B. et al. (1984) Multiple viruses in diabetes mellitus. Prog. Med. Virol. 29:197–217.
Krueger, G.R.F., Koch, B. and Ablashi, D.V. (1987) Persistent fatigue and depression in patients with antibody to human B lymphotropic virus. Lancet 2:36.
Langston, J.W., Ballard, P., Tetrud, J.W. et al. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:879–880.
Lloyd, A., Hanna, P.A. and Wakefield, D. (1988) Interferon and myalgic encephalomyelitis. Lancet 1:471.
Mackay, J.M.K., Sim, A.K., McCormick, J.N. et al. (1983) Aetiology of rheumatoid arthritis: an attempt to transmit an infective agent from patients with rheumatoid arthritis to baboons. Ann. Rheum. Dis. 42:443–7.
Melnick, J.L., Wang, S., Seidel, E. et al. (1984) Characterisation of IM virus which is frequently isolated from cerebro-spinal fluid of patients with multiple sclerosis and other chronic diseases of the central nervous system. J. Virol. 52:739–744.
Menser, M.A., Forrest, J.M. and Bransby, R.D. (1978) Rubella infection and diabetes mellitus. Lancet 1:57–60. Miller, G., Grogan, E., Rowe, D. et al. (1987) Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection. J. Inf. Dis.
Miller, J.R., Ramareddy, V.G. and Myers, J.C. (1980) Amyotrophic lateral sclerosis: search for poliovirus by nucleic acid hybridisation. Neurology 30:884–6.
Mills, B.G., Singer, F.R., Weiner, L.P. et al. (1981) Immunohistological demonstration of respiratory syncytial virus antigens in Paget’s disease of bone. Proc. Natl. Acad. Sci. USA 78:1209–1213.
Mims, C.A, (1985) Viral aetiology of diseases of obscure origin. Brit. Med. Bull. 41:63–69.
Minick, C.R., Fabricant, CG., Fabricant, J. et al. (1970) Atheroarterio-sclerosis induced by infection with a herpes virus. Am. J. Pathol. 96:673–706.
Narayan, O., Kennedy-Stoskpf, S., Sheffer, P. et al. (1983) Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. Infect. Immunity 41:67–73.
Nepon, J.T., Weiner, J.L., Pichter, M.A. et al. (1982) Identification of a haemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells. J. Exp. Med. 155:155–167.
Norval, M. and Smith, C. (1979) Search for viral nucleic acid sequences in rheumatoid cells. Ann. Rheum. Dis. 38:456–4 62. Oldstone, M.B.A. (1988) Prevention of type 1 diabetes in non obese mice by virus infection. Science 239:500–501.
Oldstone, M.B.A. (1988) Prevention of type 1 diabetes in non obese mice by virus infection. Science 239:500–501.
Onodera, T., Toniolo, A., Ray, U.R. et al. (1981) Virus induced diabetes mellitus. XX Polyendocrinopathy and auto-immunity. J. Exp. Med. 153:1457–1473
Pogo, B.G.T., Casals, J. and Elizan, T.S. (1987) A study of viral genomes and antigens in brains of patients with Alzheimer’s disease. Brain 110:907–916.
Prince, G.A., Jenson, A.B., Billups, L.C. et al. (1978) Infection of human pancreatic beta cells with mumps virus. Nature 271 :158–161
Rodriguez, M., von Wedel, R.J., Garrett, R.S. et al. (1983) Pituitary dwarfism in mice persistently infected with lymphocytic choriomeningitis virus. Lab. Investig. 49:48.
Salmi, A., Reunanen, M., Ilonen, J. et al. (1983) Intrathecal antibody synthesis to virus antigens in multiple sclerosis. Clin. Exp. Immunol. 52:214–249.
Smith, H.R. and Steinberg, A.P. (1983) Autoimmunity — a perspective. Ann. Rev. Immunol. 1:175–210.
Srinivasappa, J., Saegusa, J., Prabhakar, B.S. et al. (1986) Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. J. Virol. 57:397–401.
Wetmur, J.G., Schwartz, J. and Elizan, T.S. (1979) Nucleic acid homology studies of viral nucleic acids in idiopathic Parkinson’s disease. Arch. Neurol. 36:462–4.
Yoon, J.W., Austin, M., Onodera, T. et al. (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. New Engl. J. Med. 300:1173–9
Yoshiki, T., Mellors, R.C., Strand, M. et al. (1974) The viral envelope glycoprotein of murine leukaemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J. Exp. Med. 140:1011–1027.
Yousef, G.E., Ball, E.J., Mann, G.F. et al. (1988) Chronic enterovirus infection in patients with post-viral fatigue syndrome. Lancet i:146.
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© 1989 Plenum Press, New York
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Mims, C.A. (1989). Important Diseases with a Possible Viral Aetiology. In: Askonas, B.A., Moss, B., Torrigiani, G., Gorini, S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5712-4_13
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DOI: https://doi.org/10.1007/978-1-4684-5712-4_13
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