Important Diseases with a Possible Viral Aetiology

  • C. A. Mims
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)


There can be few of us who have not at some time or another considered a virus to account for a disease of unknown origin. Indeed as long as there are such diseases there will be suggestions that viruses are responsible. But we have to be careful because although the late Peter Medawar quite accurately described a virus as a “piece of bad news wrapped in protein” there is the alternative definition that virus is a Latin word used by doctors meaning “your guess is as good as mine”. However, viruses are unique in that they can do the following things.


Multiple Sclerosis Nucleic Acid Sequence Viral Aetiology Mumps Virus Human Herpes Virus Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Benditt, E.P., Barrett, T. and McDougall, J.K. (1983) Viruses in the aetiology of atherosclerosis. Proc. Natl. Acad. Sci. 80:6386–6389.PubMedCrossRefGoogle Scholar
  2. Datta, S.K., McConahey, P.J., Manny, N. et al. (1978) Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand Black mice II The viral envelope glycoprotein gp70. J. Exp. Med. 147:87–881.CrossRefGoogle Scholar
  3. Gamble, D.R. (1980) The epidemiology of insulin dependent diabetes, with particular reference to the relationship of virus infection to its aetiology. Epid. Rev. 2:49–70.Google Scholar
  4. Janowitz, H.D. (1981) Crohn’s disease — 50 years later. New Engl. J. Med. 304:1600–1602.PubMedCrossRefGoogle Scholar
  5. Jenson, A.B., Rosenberg, H.S. and Notkins, A.L. (1980) Pancreatic islet cell damage in children with fatal viral infections. Lancet 2:354–358.PubMedGoogle Scholar
  6. Jenson, A.B. et al. (1984) Multiple viruses in diabetes mellitus. Prog. Med. Virol. 29:197–217.PubMedGoogle Scholar
  7. Krueger, G.R.F., Koch, B. and Ablashi, D.V. (1987) Persistent fatigue and depression in patients with antibody to human B lymphotropic virus. Lancet 2:36.PubMedCrossRefGoogle Scholar
  8. Langston, J.W., Ballard, P., Tetrud, J.W. et al. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:879–880.CrossRefGoogle Scholar
  9. Lloyd, A., Hanna, P.A. and Wakefield, D. (1988) Interferon and myalgic encephalomyelitis. Lancet 1:471.PubMedCrossRefGoogle Scholar
  10. Mackay, J.M.K., Sim, A.K., McCormick, J.N. et al. (1983) Aetiology of rheumatoid arthritis: an attempt to transmit an infective agent from patients with rheumatoid arthritis to baboons. Ann. Rheum. Dis. 42:443–7.PubMedCrossRefGoogle Scholar
  11. Melnick, J.L., Wang, S., Seidel, E. et al. (1984) Characterisation of IM virus which is frequently isolated from cerebro-spinal fluid of patients with multiple sclerosis and other chronic diseases of the central nervous system. J. Virol. 52:739–744.PubMedGoogle Scholar
  12. Menser, M.A., Forrest, J.M. and Bransby, R.D. (1978) Rubella infection and diabetes mellitus. Lancet 1:57–60. Miller, G., Grogan, E., Rowe, D. et al. (1987) Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection. J. Inf. Dis. Google Scholar
  13. Miller, J.R., Ramareddy, V.G. and Myers, J.C. (1980) Amyotrophic lateral sclerosis: search for poliovirus by nucleic acid hybridisation. Neurology 30:884–6.PubMedGoogle Scholar
  14. Mills, B.G., Singer, F.R., Weiner, L.P. et al. (1981) Immunohistological demonstration of respiratory syncytial virus antigens in Paget’s disease of bone. Proc. Natl. Acad. Sci. USA 78:1209–1213.PubMedCrossRefGoogle Scholar
  15. Mims, C.A, (1985) Viral aetiology of diseases of obscure origin. Brit. Med. Bull. 41:63–69.PubMedGoogle Scholar
  16. Minick, C.R., Fabricant, CG., Fabricant, J. et al. (1970) Atheroarterio-sclerosis induced by infection with a herpes virus. Am. J. Pathol. 96:673–706.Google Scholar
  17. Narayan, O., Kennedy-Stoskpf, S., Sheffer, P. et al. (1983) Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. Infect. Immunity 41:67–73.Google Scholar
  18. Nepon, J.T., Weiner, J.L., Pichter, M.A. et al. (1982) Identification of a haemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells. J. Exp. Med. 155:155–167.CrossRefGoogle Scholar
  19. Norval, M. and Smith, C. (1979) Search for viral nucleic acid sequences in rheumatoid cells. Ann. Rheum. Dis. 38:456–4 62. Oldstone, M.B.A. (1988) Prevention of type 1 diabetes in non obese mice by virus infection. Science 239:500–501.PubMedCrossRefGoogle Scholar
  20. Oldstone, M.B.A. (1988) Prevention of type 1 diabetes in non obese mice by virus infection. Science 239:500–501.PubMedCrossRefGoogle Scholar
  21. Onodera, T., Toniolo, A., Ray, U.R. et al. (1981) Virus induced diabetes mellitus. XX Polyendocrinopathy and auto-immunity. J. Exp. Med. 153:1457–1473PubMedCrossRefGoogle Scholar
  22. Pogo, B.G.T., Casals, J. and Elizan, T.S. (1987) A study of viral genomes and antigens in brains of patients with Alzheimer’s disease. Brain 110:907–916.PubMedCrossRefGoogle Scholar
  23. Prince, G.A., Jenson, A.B., Billups, L.C. et al. (1978) Infection of human pancreatic beta cells with mumps virus. Nature 271 :158–161PubMedCrossRefGoogle Scholar
  24. Rodriguez, M., von Wedel, R.J., Garrett, R.S. et al. (1983) Pituitary dwarfism in mice persistently infected with lymphocytic choriomeningitis virus. Lab. Investig. 49:48.PubMedGoogle Scholar
  25. Salmi, A., Reunanen, M., Ilonen, J. et al. (1983) Intrathecal antibody synthesis to virus antigens in multiple sclerosis. Clin. Exp. Immunol. 52:214–249.Google Scholar
  26. Smith, H.R. and Steinberg, A.P. (1983) Autoimmunity — a perspective. Ann. Rev. Immunol. 1:175–210.CrossRefGoogle Scholar
  27. Srinivasappa, J., Saegusa, J., Prabhakar, B.S. et al. (1986) Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. J. Virol. 57:397–401.PubMedGoogle Scholar
  28. Wetmur, J.G., Schwartz, J. and Elizan, T.S. (1979) Nucleic acid homology studies of viral nucleic acids in idiopathic Parkinson’s disease. Arch. Neurol. 36:462–4.PubMedCrossRefGoogle Scholar
  29. Yoon, J.W., Austin, M., Onodera, T. et al. (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. New Engl. J. Med. 300:1173–9PubMedCrossRefGoogle Scholar
  30. Yoshiki, T., Mellors, R.C., Strand, M. et al. (1974) The viral envelope glycoprotein of murine leukaemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J. Exp. Med. 140:1011–1027.PubMedCrossRefGoogle Scholar
  31. Yousef, G.E., Ball, E.J., Mann, G.F. et al. (1988) Chronic enterovirus infection in patients with post-viral fatigue syndrome. Lancet i:146.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • C. A. Mims
    • 1
  1. 1.Department of MicrobiologyUMDS, Guy’s CampusLondon BridgeUK

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