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Important Diseases with a Possible Viral Aetiology

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Book cover The Immune Response to Viral Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 257))

Abstract

There can be few of us who have not at some time or another considered a virus to account for a disease of unknown origin. Indeed as long as there are such diseases there will be suggestions that viruses are responsible. But we have to be careful because although the late Peter Medawar quite accurately described a virus as a “piece of bad news wrapped in protein” there is the alternative definition that virus is a Latin word used by doctors meaning “your guess is as good as mine”. However, viruses are unique in that they can do the following things.

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References

  • Benditt, E.P., Barrett, T. and McDougall, J.K. (1983) Viruses in the aetiology of atherosclerosis. Proc. Natl. Acad. Sci. 80:6386–6389.

    Article  PubMed  CAS  Google Scholar 

  • Datta, S.K., McConahey, P.J., Manny, N. et al. (1978) Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand Black mice II The viral envelope glycoprotein gp70. J. Exp. Med. 147:87–881.

    Article  Google Scholar 

  • Gamble, D.R. (1980) The epidemiology of insulin dependent diabetes, with particular reference to the relationship of virus infection to its aetiology. Epid. Rev. 2:49–70.

    CAS  Google Scholar 

  • Janowitz, H.D. (1981) Crohn’s disease — 50 years later. New Engl. J. Med. 304:1600–1602.

    Article  PubMed  CAS  Google Scholar 

  • Jenson, A.B., Rosenberg, H.S. and Notkins, A.L. (1980) Pancreatic islet cell damage in children with fatal viral infections. Lancet 2:354–358.

    PubMed  CAS  Google Scholar 

  • Jenson, A.B. et al. (1984) Multiple viruses in diabetes mellitus. Prog. Med. Virol. 29:197–217.

    PubMed  CAS  Google Scholar 

  • Krueger, G.R.F., Koch, B. and Ablashi, D.V. (1987) Persistent fatigue and depression in patients with antibody to human B lymphotropic virus. Lancet 2:36.

    Article  PubMed  CAS  Google Scholar 

  • Langston, J.W., Ballard, P., Tetrud, J.W. et al. (1983) Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:879–880.

    Article  Google Scholar 

  • Lloyd, A., Hanna, P.A. and Wakefield, D. (1988) Interferon and myalgic encephalomyelitis. Lancet 1:471.

    Article  PubMed  CAS  Google Scholar 

  • Mackay, J.M.K., Sim, A.K., McCormick, J.N. et al. (1983) Aetiology of rheumatoid arthritis: an attempt to transmit an infective agent from patients with rheumatoid arthritis to baboons. Ann. Rheum. Dis. 42:443–7.

    Article  PubMed  CAS  Google Scholar 

  • Melnick, J.L., Wang, S., Seidel, E. et al. (1984) Characterisation of IM virus which is frequently isolated from cerebro-spinal fluid of patients with multiple sclerosis and other chronic diseases of the central nervous system. J. Virol. 52:739–744.

    PubMed  CAS  Google Scholar 

  • Menser, M.A., Forrest, J.M. and Bransby, R.D. (1978) Rubella infection and diabetes mellitus. Lancet 1:57–60. Miller, G., Grogan, E., Rowe, D. et al. (1987) Selective lack of antibody to a component of EB nuclear antigen in patients with chronic active Epstein-Barr virus infection. J. Inf. Dis.

    Google Scholar 

  • Miller, J.R., Ramareddy, V.G. and Myers, J.C. (1980) Amyotrophic lateral sclerosis: search for poliovirus by nucleic acid hybridisation. Neurology 30:884–6.

    PubMed  CAS  Google Scholar 

  • Mills, B.G., Singer, F.R., Weiner, L.P. et al. (1981) Immunohistological demonstration of respiratory syncytial virus antigens in Paget’s disease of bone. Proc. Natl. Acad. Sci. USA 78:1209–1213.

    Article  PubMed  CAS  Google Scholar 

  • Mims, C.A, (1985) Viral aetiology of diseases of obscure origin. Brit. Med. Bull. 41:63–69.

    PubMed  CAS  Google Scholar 

  • Minick, C.R., Fabricant, CG., Fabricant, J. et al. (1970) Atheroarterio-sclerosis induced by infection with a herpes virus. Am. J. Pathol. 96:673–706.

    Google Scholar 

  • Narayan, O., Kennedy-Stoskpf, S., Sheffer, P. et al. (1983) Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. Infect. Immunity 41:67–73.

    CAS  Google Scholar 

  • Nepon, J.T., Weiner, J.L., Pichter, M.A. et al. (1982) Identification of a haemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells. J. Exp. Med. 155:155–167.

    Article  Google Scholar 

  • Norval, M. and Smith, C. (1979) Search for viral nucleic acid sequences in rheumatoid cells. Ann. Rheum. Dis. 38:456–4 62. Oldstone, M.B.A. (1988) Prevention of type 1 diabetes in non obese mice by virus infection. Science 239:500–501.

    Article  PubMed  CAS  Google Scholar 

  • Oldstone, M.B.A. (1988) Prevention of type 1 diabetes in non obese mice by virus infection. Science 239:500–501.

    Article  PubMed  CAS  Google Scholar 

  • Onodera, T., Toniolo, A., Ray, U.R. et al. (1981) Virus induced diabetes mellitus. XX Polyendocrinopathy and auto-immunity. J. Exp. Med. 153:1457–1473

    Article  PubMed  CAS  Google Scholar 

  • Pogo, B.G.T., Casals, J. and Elizan, T.S. (1987) A study of viral genomes and antigens in brains of patients with Alzheimer’s disease. Brain 110:907–916.

    Article  PubMed  Google Scholar 

  • Prince, G.A., Jenson, A.B., Billups, L.C. et al. (1978) Infection of human pancreatic beta cells with mumps virus. Nature 271 :158–161

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez, M., von Wedel, R.J., Garrett, R.S. et al. (1983) Pituitary dwarfism in mice persistently infected with lymphocytic choriomeningitis virus. Lab. Investig. 49:48.

    PubMed  CAS  Google Scholar 

  • Salmi, A., Reunanen, M., Ilonen, J. et al. (1983) Intrathecal antibody synthesis to virus antigens in multiple sclerosis. Clin. Exp. Immunol. 52:214–249.

    Google Scholar 

  • Smith, H.R. and Steinberg, A.P. (1983) Autoimmunity — a perspective. Ann. Rev. Immunol. 1:175–210.

    Article  CAS  Google Scholar 

  • Srinivasappa, J., Saegusa, J., Prabhakar, B.S. et al. (1986) Molecular mimicry: frequency of reactivity of monoclonal antiviral antibodies with normal tissues. J. Virol. 57:397–401.

    PubMed  CAS  Google Scholar 

  • Wetmur, J.G., Schwartz, J. and Elizan, T.S. (1979) Nucleic acid homology studies of viral nucleic acids in idiopathic Parkinson’s disease. Arch. Neurol. 36:462–4.

    Article  PubMed  CAS  Google Scholar 

  • Yoon, J.W., Austin, M., Onodera, T. et al. (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. New Engl. J. Med. 300:1173–9

    Article  PubMed  CAS  Google Scholar 

  • Yoshiki, T., Mellors, R.C., Strand, M. et al. (1974) The viral envelope glycoprotein of murine leukaemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J. Exp. Med. 140:1011–1027.

    Article  PubMed  CAS  Google Scholar 

  • Yousef, G.E., Ball, E.J., Mann, G.F. et al. (1988) Chronic enterovirus infection in patients with post-viral fatigue syndrome. Lancet i:146.

    Article  Google Scholar 

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© 1989 Plenum Press, New York

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Mims, C.A. (1989). Important Diseases with a Possible Viral Aetiology. In: Askonas, B.A., Moss, B., Torrigiani, G., Gorini, S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5712-4_13

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  • DOI: https://doi.org/10.1007/978-1-4684-5712-4_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5714-8

  • Online ISBN: 978-1-4684-5712-4

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