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Molecular and Genetic Aspects of the Immune Responses to Hepatitis B Viral Antigens

  • David R. Milich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)

Summary

In the absence of an inbred animal model of hepatitis B virus (HBV) infection, several laboratories have chosen to study the murine immune response to HBV-encoded proteins as immunogens as opposed to an infectious agent. This article reviews the immunogenicity, the fine specificity of T and B cell recognition of HBV antigens, and the genetic influences that regulate these responses. It is anticipated that this approach will increase our understanding of immune-mediated viral clearance mechanisms during HBV infection, and may provide the framework for the design of second and third generation HBV vaccines.

Keywords

Synthetic Peptide Antibody Production Cell Epitope Cell Site Antibody Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David R. Milich
    • 1
  1. 1.Department of Molecular BiologyResearch Institute of Scripps ClinicLa JollaUSA

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