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Lymphocytic Choriomeningitis Virus-specific Delayed-type Hypersensitivity Reaction in Mice

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The Immune Response to Viral Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 257))

Abstract

The first description of a local delayed-type hypersen-sitivity (DTH) reaction dates as far back as 1798, when E. Jenner commented on the response following the cutaneous application of poxvirus in a woman, who, 31 years previously, had had cowpox: “It is remarkable that variolous matter, when the system is disposed to reject it, should excite inflammation on the part to which it is applied more speedily than when it produces the Small Pox. Indeed it becomes almost a criterion by which we can determine whether the infection will be received or not. It seems as if a change, which endures through life, had been produced in the action, or disposition to action, in the vessels of the skin; and it is remarkable too, that whether this change has been effected by the Small Pox, or the Cow Pox, that the disposition to sudden cuticular inflammation is the same on the application of variolous matter”.

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Authors and Affiliations

  1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Martinistrasse 52, 2000, Hamburg 20, Federal Republic of Germany

    Fritz Lehmann-Grube & Demetrius Moskophidis

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  1. Fritz Lehmann-Grube
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  2. Demetrius Moskophidis
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Editors and Affiliations

  1. National Institute for Medical Research, London, UK

    B. A. Askonas

  2. National Institutes of Health, Bethesda, Maryland, USA

    B. Moss

  3. World Health Organization, Geneva, Switzerland

    G. Torrigiani

  4. Fondazione Internazionale Menarini, Florence, Italy

    S. Gorini

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© 1989 Plenum Press, New York

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Lehmann-Grube, F., Moskophidis, D. (1989). Lymphocytic Choriomeningitis Virus-specific Delayed-type Hypersensitivity Reaction in Mice. In: Askonas, B.A., Moss, B., Torrigiani, G., Gorini, S. (eds) The Immune Response to Viral Infections. Advances in Experimental Medicine and Biology, vol 257. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5712-4_10

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  • DOI: https://doi.org/10.1007/978-1-4684-5712-4_10

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