Lymphocytic Choriomeningitis Virus-specific Delayed-type Hypersensitivity Reaction in Mice

  • Fritz Lehmann-Grube
  • Demetrius Moskophidis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 257)


The first description of a local delayed-type hypersen-sitivity (DTH) reaction dates as far back as 1798, when E. Jenner commented on the response following the cutaneous application of poxvirus in a woman, who, 31 years previously, had had cowpox: “It is remarkable that variolous matter, when the system is disposed to reject it, should excite inflammation on the part to which it is applied more speedily than when it produces the Small Pox. Indeed it becomes almost a criterion by which we can determine whether the infection will be received or not. It seems as if a change, which endures through life, had been produced in the action, or disposition to action, in the vessels of the skin; and it is remarkable too, that whether this change has been effected by the Small Pox, or the Cow Pox, that the disposition to sudden cuticular inflammation is the same on the application of variolous matter”.


Influenza Virus Major Histocompatibility Gene Complex Sendai Virus Virus Elimination Lymphocytic Choriomeningitis 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Fritz Lehmann-Grube
    • 1
  • Demetrius Moskophidis
    • 1
  1. 1.Heinrich-Pette-Institut für Experimentelle Virologie und ImmunologieUniversität HamburgHamburg 20Federal Republic of Germany

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